FLUOROQUINOLONES (Veterinary—Systemic) - College of ...

22.7 mg (Rx) [Orbax Tablets].
68 mg (Rx) [Orbax Tablets].
Packaging and storage: Store between 2 and 30 ºC (36 and 86
ºF), {R-98} unless otherwise specified by manufacturer.
Table I. Pharmacology/Pharmacokinetics—Intravenous administration
USP requirements: Not in USP. {R-105}
Developed: 02/17/00
Revised: 11/6/06
Interim revision: 03/28/03
CIPROFLOXACIN
Elimination VolD,
VolD, steady
Dose
half-life area
state
Clearance
Species
(mg/kg)
(hours) (L/kg)
(L/kg)
(mL/min/kg)
Cats {R-182} 10 4.53 ± 0.74 3.85 ± 1.34 10.7 ± 4.67
Dogs {R-117} 2.5
3.00 ± 0.64 4.88 ± 0.68
5
10
2.16 ± 0.78
2.55 ± 0.62
3.06 ± 0.75
2.96 ± 0.43
DANOFLOXACIN
Species
Calves, 4 to 6 weeks of
age {R-160}
Calves, 4 months of
age {R-155}
Calves, 112 kg body
weight {R-162}
Calves, 180 kg body
weight, with acute
pneumonia {R-158}
{R-151; 153}
Dose
(mg/kg)
1.25
1.25
5
1.25
Elimination
half-life
(hours)
7.4 ± 1.8
2.65 ± 0.16
2.9
6.26 ± 2.27
VolD,
area
(L/kg)
3.90 ± 0.30
3.99 ± 1.49
VolD, steady
state
(L/kg)
4.3 ± 0.8
3.12 ± 0.13
3.44 ± 1.13
Clearance
(mL/min/kg)
9.1 ± 3.3
Calves
Heifers
Steers
6
6
4.2 ± 0.29
4.8 ± 0.86
2.6 ± 0.10
2.7 ± 0.19
Cattle, lactating {R-161} 1.25 0.91 ± 0.19 2.04 ± 1.10
Camels {R-49} 1.25 5.37 ± 0.50 2.53 ± 0.18 7.33 ± 0.33
Chickens {R-170} 5 6.73 10.2 23.5
Goats {R-168}
{R-169}
Pigs, 10 kg body
weight {R-162}
Pigs, 25 to 39 kg body
weight {R-164}
Healthy
With induced
gastrointestinal
Sheep {R-165}
{R-166}
{R-167}
infection*
DIFLOXACIN
1.25
1.25
5
2.4
2.5
1.25
1.25
1.25
4.67 ± 0.45
1.35 ± 0.06
8
6.7 ± 0.8
9.4 ± 0.5
3.39 ± 0.75
3.35 ± 0.23
2.08 ± 0.64
Elimination
half-life
(hours)
VolD,
area
(L/kg)
3.02 ± 0.28
1.41 ± 0.15
5.2 ± 0.9
3.8 ± 0.4
2.76 ± 0.17
2.76 ± 0.16
1.9 ± 0.7
VolD, steady
state
(L/kg)
© 2007 The United States Pharmacopeial Convention All rights reserved 16
17 ± 1
7.5 ± 1.3
9.5 ± 0.3
9.8 ± 0.6
9.5 ± 1.2
4.8 ± 0.3
11.8 ± 2.2
10.5 ± 0.7
11.1 ± 3.4
Dose
Clearance
Species
(mg/kg)
(mL/min/kg)
Goats {R-185} 5 6.30 ± 0.11 1.1 ± 0.01 2.16 ± .002
Rabbits {R-184} 5 3.25 ± 0.03 1.51 ± 0.16 9.83 ± 1.58
ENROFLOXACIN
Species
Alligators, American {R-
Elimination VolD,
VolD, steady
Dose Compound half-life area
state
Clearance
(mg/kg) measured (hours) (L/kg)
(L/kg)
(mL/min/kg)
5 Enrofloxacin 21.1 ± 11.8 3.71 ± 0.97 3.39 ± 0.84 0.78 ± 0.35