Hereditary Pelger-Huet Change

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Blood Cell Identification – Graded BCK/BCP-02 BCK BCP Referees Participants Participants Performance Identification No. % No. % No. % Evaluation Eosinophil, any stage 23 95.0 1185 59.9 2879 99.0 Good Neutrophil, segmented or band Neutrophil with Pelger-Huët nucleus (acquired or congenital) 1 5.0 398 20.1 10 0.3 Unacceptable* - - 287 14.5 9 0.3 Unacceptable The arrow designates an eosinophil that lies adjacent to a neutrophil with Pelger-Huet nucleus. The eosinophil was correctly identified by 95.0% of referees and 83.2% of BCK and BCP total participants. While both cells are of a similar size, the smaller pale salmon-colored specific granules of the neutrophil contrast with the distinctive uniform coarse orange-red granules of the eosinophil. In analyzing participant results, the Scientific Committee noted that BCK participants had a poorer performance (59.9%) compared to BCP participants (99.0%) in identifying the arrowed cell as an eosinophil. On review, slight color differences were noted between the Photomicrograph versus the Photopage for this graded challenge. *Hence, the Scientific Committee has decided that both “Neutrophil, segmented or band” and “Neutrophil with Pelger-Huet nucleus” are acceptable answers for BCK participants only (code 30 = Scientific Committee Decision). Participants using photomicrographs are reminded to view images using a slide projector in a darkened room or an illuminated, magnifying hand-held viewer. The majority of participants now subscribe to the CAP’s color photograph products for Blood Cell Identification. With the increasing use of digital imagery and the advancements of color enhancing technology, it is recommended that you consider enrolling in these products. The CAP’s color photograph products offer you larger images for more accurate resulting as well as a supplementary CD-ROM, giving you the ability to digitally project and view the images in greater detail. Please refer to the 2008 Surveys catalog for more information. 3
Blood Cell Identification – Graded BCK/BCP-03 4 BCK BCP Referees Participants Participants Performance Identification No. % No. % No. % Evaluation Basophil, any stage 23 100.0 1972 99.5 2895 99.6 Good The arrow designates a basophil as correctly identified by 100.0% of referees and 99.6% of participants. All basophils are characterized by a moderate number of densely stained coarse granules of varying sizes and shapes. These granules appear larger than neutrophilic granules and often obscure the nucleus. An uneven distribution of granules or partial degranulation may be observed (not seen in this particular basophil). Depending on the Wright stain preparation, the granules may appear purple, red or a deep blue-black.
Page 1: Blood Cell Identification - Graded
Page 5 and 6: Blood Cell Identification - Graded
Page 7 and 8: Blood Cell Identification - Ungrade
Page 9 and 10: Blood Cell Identification - Ungrade
Page 11 and 12: Discussion The CBC results and the

Hereditary Pelger-Huet Change

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