Acromegaly - The Annual Endocrine Society of Australia Seminar ...
Acromegaly - The Annual Endocrine Society of Australia Seminar ...
Acromegaly - The Annual Endocrine Society of Australia Seminar ...
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Limitations <strong>of</strong> Guideline Development<br />
<strong>The</strong> biochemical diagnosis <strong>of</strong> acromegaly and the biochemical monitoring <strong>of</strong><br />
therapy is controversial<br />
Interpretation <strong>of</strong> biochemical results<br />
• Variability between and within assays<br />
• Assays are <strong>of</strong> variable sensitivity<br />
Correlation <strong>of</strong> GH and IGF-1 values and morbidity<br />
outcomes unclear<br />
What are appropriate biochemical goals?<br />
• Epidemiologic studies provide the best evidence for GH and<br />
IGF-1 endpoints<br />
• No clear consensus on how biochemical goals impact on<br />
morbidity endpoints<br />
Limited prospective, controlled studies comparing therapeutic<br />
interventions
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