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Reference Guide on Medical Testimony - Federal Judicial Center

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<str<strong>on</strong>g>Reference</str<strong>on</strong>g> Manual <strong>on</strong> Scientific Evidence<br />

diagnosis” to describe the process by which causes of the patient’s c<strong>on</strong>diti<strong>on</strong> are<br />

identified, particularly causes external to the patient. 20 Additi<strong>on</strong>ally, courts sometimes<br />

characterize causal reas<strong>on</strong>ing as “differential etiology,” a term not used in<br />

medical practice, but <strong>on</strong>e that more closely suggests the determinati<strong>on</strong> of cause. 21<br />

For the sake of clarity and c<strong>on</strong>sistency, this reference guide uses the term “differential<br />

diagnosis” in its traditi<strong>on</strong>al medical sense, that is, referring to the diagnosis<br />

of disease, and refers to the process of identifying external causes of diseases<br />

and c<strong>on</strong>diti<strong>on</strong>s as “determining cause,” “determining external cause,” or some<br />

similar phrase, as the circumstances warrant.<br />

To add a further level of complexity, courts also use the terms general causati<strong>on</strong><br />

and specific causati<strong>on</strong>. General causati<strong>on</strong> is established by dem<strong>on</strong>strating, often<br />

through a review of scientific and medical literature, that exposure to a substance<br />

can cause a particular disease (e.g., that smoking cigarettes can cause lung<br />

cancer). Specific, or individual, causati<strong>on</strong>, however, is established by dem<strong>on</strong>strating<br />

that a given exposure is the cause of an individual’s disease (e.g., that a<br />

specific plaintiff’s lung cancer was caused by his smoking). 22 Physicians may<br />

offer expert opini<strong>on</strong> <strong>on</strong> both specific and general causati<strong>on</strong>, 23 although perhaps<br />

more comm<strong>on</strong>ly <strong>on</strong> specific causati<strong>on</strong> as it relates to a patient’s medical c<strong>on</strong>di-<br />

20. See, e.g., Kannankeril v. Terminix Int’l, Inc., 128 F.3d 802, 807 (3d Cir. 1997) (court recognized<br />

differential diagnosis “as a technique that involves assessing causati<strong>on</strong> with respect to a particular<br />

individual” (citing In re Paoli R.R. Yard PCB Litig., 35 F.3d 717, 758 (3d Cir. 1994), cert. denied, 513<br />

U.S. 1190 (1995))); Nati<strong>on</strong>al Bank of Commerce v. Associated Milk Producers, Inc., 22 F. Supp. 2d<br />

942, 963 (E.D. Ark. 1998) (plaintiff could not show, under differential diagnosis approach, that c<strong>on</strong>taminated<br />

milk caused his cancer), aff’d, 191 F.3d 858 (8th Cir. 1999); Mancuso v. C<strong>on</strong>solidated Edis<strong>on</strong><br />

Co., 967 F. Supp. 1437, 1453 (S.D.N.Y. 1997) (proffered expert failed to c<strong>on</strong>duct a differential diagnosis<br />

to exclude exposure to substances other than PCBs as the cause of plaintiffs’ ailments).<br />

21. See, e.g., Westberry v. Gummi, 178 F.3d 257, 262 (4th Cir. 1999) (differential etiology analysis<br />

of talc as the cause of sinus problems); Synder v. Upjohn Co., 172 F.3d 58 (9th Cir. 1999) (unpublished<br />

table decisi<strong>on</strong>) (text at No. 97-55912, 1999 WL 77975 (9th Cir. Feb. 12, 1999)) (differential etiology<br />

analysis of Halci<strong>on</strong> as the cause of criminal behavior).<br />

22. The issues of general causati<strong>on</strong> and specific causati<strong>on</strong> are addressed in detail in Michael D.<br />

Green et al., <str<strong>on</strong>g>Reference</str<strong>on</strong>g> <str<strong>on</strong>g>Guide</str<strong>on</strong>g> <strong>on</strong> Epidemiology §§ V, VII, and Bernard D. Goldstein & Mary Sue<br />

Henifin, <str<strong>on</strong>g>Reference</str<strong>on</strong>g> <str<strong>on</strong>g>Guide</str<strong>on</strong>g> <strong>on</strong> Toxicology §§ III–IV, in this manual. The distincti<strong>on</strong> between general<br />

causati<strong>on</strong> and specific causati<strong>on</strong> is discussed in Zwillinger v. Garfield Slope Housing Corp., No. CV 94-<br />

4009, 1998 WL 623589, at *19–*20 (E.D.N.Y. Aug. 17, 1998) (plaintiff’s expert did not offer general<br />

causati<strong>on</strong> evidence that outgassing from carpet could cause ailments suffered by plaintiff); Nati<strong>on</strong>al<br />

Bank of Commerce v. Associated Milk Producers, Inc., 22 F. Supp. 2d 942, 963 (E.D. Ark. 1998)<br />

(although differential diagnosis “‘is undoubtedly important to the questi<strong>on</strong> of ‘specific causati<strong>on</strong>,’’”<br />

plaintiff must provide expert opini<strong>on</strong> <strong>on</strong> the issue of “‘general causati<strong>on</strong>’” based <strong>on</strong> a scientifically valid<br />

methodology (quoting Cavallo v. Star Enter., 892 F. Supp. 756, 771 (E.D. Va. 1995), aff’d in part, rev’d<br />

in part, 100 F.3d 1150 (4th Cir. 1996), cert. denied, 522 U.S. 1044 (1998))), aff’d, 191 F.3d 858 (8th Cir.<br />

1999).<br />

23. See In re Joint E. & S. Dist. Asbestos Litig., 964 F.2d 92, 96 (2d Cir. 1992); Landrigan v.<br />

Celotex Corp., 605 A.2d 1079, 1086 (N.J. 1992) (permitting clinician to testify to specific causati<strong>on</strong><br />

based <strong>on</strong> epidemiology). But see Sutera v. Perrier Group of Am., Inc., 986 F. Supp. 655, 662 (D. Mass.<br />

1997) (physician not qualified to testify <strong>on</strong> epidemiology). See Michael D. Green et al., <str<strong>on</strong>g>Reference</str<strong>on</strong>g><br />

<str<strong>on</strong>g>Guide</str<strong>on</strong>g> <strong>on</strong> Epidemiology, § VII, in this manual.<br />

444

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