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THIOPENTAL Catalog Number: 1661002 Revision Date: December 24, 2009 Vapor Density: n/f Specific Gravity: > 1 Solubility in Water: Slightly soluble Fat Solubility: n/f Other Solubility: n/f Partition Coefficient: n-octanol/water: 2.85 Percent Volatile: n/f Reactivity in Water: n/f Explosive Properties: n/f Oxidizing Properties: n/f Formula: C11H18N2O2S Molecular Weight: 242.37 Copyright © 2009 The United States Pharmacopeial Convention, Inc. All Rights Reserved. n/f = not found Page 4 of 6
THIOPENTAL Catalog Number: 1661002 Revision Date: December 24, 2009 Conditions to Avoid: n/f Incompatibilities: Decomposition Products: Stable? Yes Oral Rat: Oral Mouse: n/f Irritancy Data: LD50: 600 mg/kg Other Toxicity Data: Intraperitoneal Mouse LD50: 110 mg/kg Intravenous Mouse LD50: 70 mg/kg Corrosivity: n/f n/f Sensitization Data: n/f Listed as a Carcinogen by: Other Carcinogenicity Data: No Mutagenicity Data: n/f Reproductive and Developmental Effects: Ecological Information: n/f Strong oxidizing agents When heated to decomposition, material emits very toxic fumes NOx and SOx. Emits toxic fumes under fire conditions. Hazardous Polymerization? No SECTION 10 - STABILITY AND REACTIVITY SECTION 11 - TOXICOLOGICAL PROPERTIES NTP: No IARC: No OSHA: No Thiopental crosses the placenta, but it is taken up by the fetal liver and is slow to reach concentrations high enough to cause depression in the fetal brain. Even though chronic barbiturate use during pregnancy has been associated with adverse effects, no such effects have been reported during the first trimester with thiopental induction anesthesia. There was no increase in frequencies of birth defects in 152 women who were administered thiopental during the first trimester of pregnancy. Thiopental did not increase birth defects in studies with rats and mice treated during pregnancy with 1.5 - 3 times the usual human dose of thiopental. There were no defects observed in the offspring of female mice receiving 100 mg/kg by injection on day 11 of pregnancy; some reduction in fetal weight was found with doses of 50 mg or more per kg. In pregnant rats injected with 50 and 100 mg on day 4 of pregnancy, no defective offspring were found. SECTION 12 - ECOLOGICAL INFORMATION SECTION 13 - DISPOSAL CONSIDERATIONS Disposal: Dispose of waste in accordance with all applicable Federal, State, and local laws. Additionally, because this is a controlled substance, notify local DEA office for appropriate disposal procedures. SECTION 14 -TRANSPORT INFORMATION Shipping Name: n/f Class: n/f UN Number: n/f Packing Group: n/f Additional Transport Information: n/f Copyright © 2009 The United States Pharmacopeial Convention, Inc. All Rights Reserved. n/f = not found Page 5 of 6
Page 1 and 2: Material Safety Data Sheet 12601 Tw
Page 3: THIOPENTAL Catalog Number: 1661002

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