Anaplasmosis as a Mimicker of TTP/HUS - American College of ...

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Laboratory Assessment • Tbili-0.9 • AST-181 • ALT-90 • Alk Phos-97 • LDH-619 • D-dimer >3.2 • ADAMSTS13 activity-pending • von Willebrand factor cleaving protease • Function to degrade unusually large von Willebrand factor (ULVWF). • Deficiency leads to accumulation of ULVWF, platelet aggregation, and subsequent thrombi formation • Activity level decreased in TTP
Over the next 48 hrs… • He was given IVF, started on empiric antibiotics (vancomycin, zosyn, ciprofloxacin) and transferred to the ICU for urgent plasma exchange • His mental status began to improve somewhat, even before plasma exchange , and his haptoglobin returned normal (135), so a search for other causes of renal failure, thrombocytopenia and mental status changes was begun
Page 1 and 2: TTP or not TTP? Joshua Barocas , MD
Page 3 and 4: Case Presentation PMH: CAD s/p 4v C
Page 5: Laboratory Assessment MCV-90.4 14.6
Page 9 and 10: Case Summary 59 y/o male presents w
Page 11 and 12: TTP/HUS vs. Anaplasmosis TTP/HUS
Page 13 and 14: What to order • SMEAR (evidence o
Page 15 and 16: No. No. in parenthesis is mean annu
Page 17 and 18: New Ehrlichia Species • Close rel
Page 19 and 20: Conclusions • Anaplasmosis can pr
Page 21 and 22: Acknowledgements • American Colle

Anaplasmosis as a Mimicker of TTP/HUS - American College of ...

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