3. Anal cancer - HIV-NAT

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Disclosures • Merck and Co- study investigator, research grant support, advisory boards
HPV infection and productive life cycle Virus introduced through microabrasion Infectious virions shed Virion assembly Viral DNA replication Late HPV protein production L1 & L2 Virus infection Early HPV protein production E1, E2, E4, E5, E6, & E7 Adapted from Doorbar J. J Clin Virol. 2005;32S:S7–S15.
Page 1: AIN/anal cancer Joel Palefsky, M.D.
Page 5 and 6: Spectrum of HPV Disease Morphologic
Page 7 and 8: Anal and cervical cancer incidence
Page 9 and 10: HPV Infection HIV Infection HPV HPV
Page 11: Prevalence, % Prevalence of anal HP
Page 14 and 15: Case 1 45 year old HIV+ woman • R
Page 16 and 17: Case 1 question 1- What is the diff
Page 18 and 19: Why? • Bleeding per rectum • PA
Page 20 and 21: Case 1 question 2 What is the appro
Page 22 and 23: Superficially Invasive SCCA Detecte
Page 24 and 25: Case 2 35 year old HIV+ MSM • HIV
Page 26 and 27: Case 2 question 1 What is the appro
Page 28 and 29: AIN 3
Page 30 and 31: Case 2-question 2 What is the best
Page 32 and 33: Take home messages • Very high ra
Page 34 and 35: What can we do now? • Collect dat
Page 36 and 37: Related Cases Quadrivalent HPV vacc
Page 38: ขอขอบคุณส ำห

3. Anal cancer - HIV-NAT

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