DISODIUM SUCCINATE CAS N°: 150-90-3
DISODIUM SUCCINATE CAS N°: 150-90-3
DISODIUM SUCCINATE CAS N°: 150-90-3
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
OECD SIDS<br />
<strong>DISODIUM</strong> <strong>SUCCINATE</strong><br />
5. TOXICITY ID <strong>150</strong>-<strong>90</strong>-3<br />
DATE: 27.01.2003<br />
5.2.1 SKIN IRRITATION<br />
5.2.2 EYE IRRITATION<br />
5.3 SENSITIZATION<br />
5.4 REPEATED DOSE TOXICITY<br />
Species : rat<br />
Sex : male/female<br />
Strain : Crj: CD(SD)<br />
Route of admin. : gavage<br />
Exposure period : Males; for 52 days<br />
Females; from 14 days before mating to day 4 of lactation<br />
Frequency of<br />
: Once daily<br />
treatment<br />
Post obs. period : 1 day<br />
Doses : 0(vehicle), 100, 300, 1000 mg/kg bw/day<br />
Control group : yes, concurrent vehicle<br />
NOAEL : >= 600 mg/kg bw<br />
Method : OECD combined study TG422<br />
Year : 2002<br />
GLP : Yes<br />
Test substance : other TS: See Remark<br />
Remark : 1)Test substance: disodium succinate hexahydrate (<strong>CAS</strong> No. 6106-21-4),<br />
Nippon Shokubai Co., Ltd., Purity 99.9%, Lot No. 9P01B<br />
2)Route: oral (gavage)<br />
3)No. of animals/group: males 12, females 12<br />
Result : The NOAEL of disodium succinate hexahydrate was greater than or equal<br />
to 1000 mg/kg bw/day for males and females. It becomes greater than or<br />
equal to 600 mg/kg bw/day as disodium succinate.<br />
1) Mortality and clinical signs<br />
No death occurred in males and females in any group throughout the<br />
treatment period.<br />
As the changes in clinical signs, loosening of stool was observed in 1 and 4<br />
males in the 100 and 1000 mg/kg groups and 1 female in the 1000 mg/kg<br />
group, respectively. This finding was a mild one and not accompanied by<br />
dirty hair in any group. One male in the 100mg/kg group and 1 female in<br />
the 1000 mg/kg group showed this finding in 1 day only, but 3 males except<br />
one male in the 1000 mg/kg group showed this finding in 3 to 4 days. In<br />
addition, for males, there were alopecia in 2 and 3 animals in the 300 and<br />
1000 mg/kg groups, eschar in 1 and 2 animals in the 300 and 1000 mg/kg<br />
groups, ocular discharge in 1 animal each in the 300 and 1000 mg/kg<br />
groups, nasal discharge in 2 animals each in the 300 and 1000 mg/kg<br />
groups and salivation in 1 animal in the 1000 mg/kg group, respectively.<br />
For females, there was alopecia in 1, 2, 3 and 1 animals in the control, 100,<br />
300 and 1000 mg/kg groups, eschar in 1 animal each in the 100 and 1000<br />
mg/kg groups and salivation in 1 animal in the 1000 mg/kg group,<br />
respectively.<br />
2) Body weight<br />
There was no significant difference between the treatment groups and the<br />
UNEP PUBLICATIONS 43
Change language