Assessment of some biochemical tests in liver diseases

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Investigation of Abnormal LFTs PRINCIPLES 2.5% of population have raised LFTs Normal LFTs do not exclude liver disease Interpret LFTs in clinical context Take a careful history for risk factors, drugs (inc OTCs), alcohol, comorbidity, autoimmunity Physical examination for liver disease If mild abnormalities and no risk factors or suggestion of serious liver disease , repeat LFTs after an interval (with lifestyle modification)
Investigation of Abnormal LFTs - Raised ALT / AST In Egypt please do Hepatitis serology markers (B, C) Iron studies – transferrin saturation + ferritin Autoantibodies & immunoglobulins Consider caeruloplasmin Alpha-1- antitrypsin
Page 1 and 2: Assessment of some biochemical test
Page 3 and 4: Liver Function Test Interpretation
Page 5 and 6: Liver Function Test Advantages •
Page 7 and 8: Serum enzyme tests They indicate ty
Page 9 and 10: Markers of Hepatocellular damage (T
Page 11 and 12: SGPT & SGOT Minor increase (< 2 tim
Page 13 and 14: SGPT & SGOT Moderate increase (5-15
Page 15 and 16: Ischemic hepatitis sudden and massi
Page 17 and 18: SGPT & SGOT Cirrhotic patients may
Page 19 and 20: The aspartate aminotransferase plat
Page 21 and 22: What does an APRI score of 1.09 tel
Page 23 and 24: GGT may be necessary to evaluate th
Page 25 and 26: Alkaline phosphates (ALP) Depressed
Page 27 and 28: GGT GGT is a sensitive indicator of
Page 29 and 30: GGT GGT increased in: -Hepatic meta
Page 31 and 32: S.bilirubin Increased in both chole
Page 33 and 34: S.albumin S.albumin: - Accounts for
Page 35 and 36: Modified Child-Turcotte-Pugh progno
Page 37 and 38: FibroTest & ActiTest
Page 39 and 40: ActiTest FibroTest (combines the sa
Page 41 and 42: Necroinflammatory activity grade (M
Page 43: What are the most frequent causes o

Assessment of some biochemical tests in liver diseases

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