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College of Veterinary Medicine Western University of Health Sciences

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Four CVM Students Conduct Research<br />

in Comparative Genomics<br />

UNDERSTANDING HOW MAMMALIAN GENOMES ENCODE PHENOTYPES<br />

such as physiological processes, behavior, morphological<br />

characteristics and clinically relevant traits is extremely<br />

important in order to advance human and veterinary<br />

medicine. The sequencing <strong>of</strong> multiple mammalian genomes<br />

makes it possible to explore the genetic basis <strong>of</strong> these<br />

phenotypes in both animals and humans using bioinformatics<br />

and comparative genomics approaches.<br />

Four students from <strong>Western</strong> <strong>University</strong> <strong>of</strong> <strong>Health</strong> <strong>Sciences</strong><br />

<strong>College</strong> <strong>of</strong> <strong>Veterinary</strong> <strong>Medicine</strong> (CVM) have begun<br />

independent comparative genomics research projects under<br />

the guidance <strong>of</strong> an interdisciplinary team <strong>of</strong> researchers<br />

comprised <strong>of</strong> Dr. Kristopher Irizarry, Assistant Pr<strong>of</strong>essor <strong>of</strong><br />

Bioinformatics, Genetics and Genomics, CVM; Dr. Peggy<br />

Schmidt, Assistant Pr<strong>of</strong>essor <strong>of</strong> Population <strong>Medicine</strong>, CVM;<br />

and Dr. Katherine Mitsouras, Assistant Pr<strong>of</strong>essor <strong>of</strong><br />

Biochemistry, <strong>College</strong> <strong>of</strong> Osteopathic <strong>Medicine</strong> <strong>of</strong> the Pacific,<br />

<strong>Western</strong> <strong>University</strong> <strong>of</strong> <strong>Health</strong> <strong>Sciences</strong>.<br />

Asked about the capacity <strong>of</strong> veterinary<br />

students to engage in such cutting edge<br />

genomics research, Dr. Irizarry stated,“Our<br />

veterinary students are uniquely suited to<br />

independent research projects and many can<br />

function at the level <strong>of</strong> graduate students in a<br />

biomedical PhD program. One <strong>of</strong> the strengths<br />

<strong>of</strong> a ‘problem based learning curriculum’ is that it<br />

produces students who are highly capable <strong>of</strong><br />

identifying problems and solving them–exactly the<br />

traits desired in a genomics researcher. Not only<br />

will these students enjoy working in comparative<br />

genomics, they will likely make novel<br />

discoveries, contribute real genomics data and<br />

hopefully author a publication based on their<br />

research.”<br />

Kristopher Irizarry Peggy Schmidt Katherine Mitsouras<br />

The unique expertise <strong>of</strong> the faculty coupled with the four self-directed and<br />

motivated students has contributed to some truly exciting student projects this<br />

summer including:<br />

• identifying regions <strong>of</strong> the canine genome associated with susceptibility to cancer<br />

(Gabrielle Galgoul, DVM ’11),<br />

• analysis <strong>of</strong> canine genetic variation contributing to altered protein structure and<br />

function (Audrey Hoholm, DVM ’11),<br />

• characterizing genetic variation in genes encoding neurotransmitter receptors in<br />

both human and canine genomes associated with anxiety related behavior<br />

(Jae Yoo, DVM ’11) and<br />

• investigating genetic variation and diversity within enzymes involved in<br />

glycolysis across animal genomes (Matthew Singer, DVM ’11).<br />

12

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