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<strong>Misuse</strong> <strong>and</strong> <strong>Abuse</strong> <strong>of</strong> <strong>Opioid</strong> <strong>Analgesics</strong><br />

– <strong>the</strong> <strong>Role</strong> <strong>of</strong> <strong>the</strong> <strong>Internet</strong><br />

H. Siemann, J. Schnell, N. Scherbaum<br />

LVR Hospital Essen,<br />

Clinic for Dependent Behavior <strong>and</strong><br />

Addiction Medicine<br />

University <strong>of</strong> Duisburg-Essen,<br />

Germany


<strong>Misuse</strong> <strong>and</strong> <strong>Abuse</strong> <strong>of</strong> <strong>Opioid</strong> <strong>Analgesics</strong> – <strong>the</strong> <strong>Role</strong> <strong>of</strong> <strong>the</strong> <strong>Internet</strong><br />

09/18/2009<br />

<strong>Opioid</strong> <strong>Analgesics</strong><br />

• Prescription Drugs<br />

– Tramadol, Tilidine, Codeine, Loperamide<br />

– Easy to prescribe<br />

• Schedule III Drugs according to <strong>the</strong><br />

German Narcotics Act (BtmG)<br />

– Morphine, Methadone, Fentanyl,<br />

Buprenorphine, Oxycodone<br />

– Special conditions to be fulfilled for a valid<br />

presciption<br />

Holger Siemann (holger.siemann@lvr.de)<br />

2


<strong>Misuse</strong> <strong>and</strong> <strong>Abuse</strong> <strong>of</strong> <strong>Opioid</strong> <strong>Analgesics</strong> – <strong>the</strong> <strong>Role</strong> <strong>of</strong> <strong>the</strong> <strong>Internet</strong><br />

09/18/2009<br />

Prescription Rate<br />

Holger Siemann (holger.siemann@lvr.de)<br />

3


<strong>Misuse</strong> <strong>and</strong> <strong>Abuse</strong> <strong>of</strong> <strong>Opioid</strong> <strong>Analgesics</strong> – <strong>the</strong> <strong>Role</strong> <strong>of</strong> <strong>the</strong> <strong>Internet</strong><br />

09/18/2009<br />

Non-Scheduled <strong>Opioid</strong>s<br />

• Tramadol<br />

– Pain management (post-surgery<br />

treatment, injury treatment)<br />

• Tilidine + Naloxone (Valoron N ® )<br />

– Higher analgesic potency<br />

– Prevention <strong>of</strong> parenteral drug abuse by<br />

combination with <strong>the</strong> µ-receptor antagonist<br />

Naloxone<br />

Holger Siemann (holger.siemann@lvr.de)<br />

4


<strong>Misuse</strong> <strong>and</strong> <strong>Abuse</strong> <strong>of</strong> <strong>Opioid</strong> <strong>Analgesics</strong> – <strong>the</strong> <strong>Role</strong> <strong>of</strong> <strong>the</strong> <strong>Internet</strong><br />

09/18/2009<br />

Aim <strong>of</strong> <strong>the</strong> Study<br />

• To assess <strong>the</strong> role <strong>of</strong> <strong>the</strong> internet<br />

regarding <strong>the</strong> abuse <strong>of</strong> prescription<br />

opioids<br />

– <strong>Role</strong> as a trading platform<br />

– <strong>Role</strong> as an information system<br />

Holger Siemann (holger.siemann@lvr.de)<br />

5


<strong>Misuse</strong> <strong>and</strong> <strong>Abuse</strong> <strong>of</strong> <strong>Opioid</strong> <strong>Analgesics</strong> – <strong>the</strong> <strong>Role</strong> <strong>of</strong> <strong>the</strong> <strong>Internet</strong><br />

09/18/2009<br />

Methods<br />

• Analysis <strong>of</strong> <strong>the</strong> first 50 websites provided by<br />

<strong>the</strong> leading search engine Google for <strong>the</strong> 3<br />

search terms:<br />

– Tramal (registered trademark)<br />

– Tramadol<br />

– Tramadol rezeptfrei (no need for a valid<br />

prescription)<br />

• 150 websites<br />

• No focus on Tilidine due to <strong>the</strong> combination<br />

with Naloxone <strong>and</strong> <strong>the</strong> low abuse potential<br />

Holger Siemann (holger.siemann@lvr.de)<br />

6


<strong>Misuse</strong> <strong>and</strong> <strong>Abuse</strong> <strong>of</strong> <strong>Opioid</strong> <strong>Analgesics</strong> – <strong>the</strong> <strong>Role</strong> <strong>of</strong> <strong>the</strong> <strong>Internet</strong><br />

09/18/2009<br />

Results<br />

• Analysis <strong>of</strong> 150 websites<br />

• About 800 webpages<br />

• Following some discussion boards in<br />

addition<br />

Holger Siemann (holger.siemann@lvr.de)<br />

7


<strong>Misuse</strong> <strong>and</strong> <strong>Abuse</strong> <strong>of</strong> <strong>Opioid</strong> <strong>Analgesics</strong> – <strong>the</strong> <strong>Role</strong> <strong>of</strong> <strong>the</strong> <strong>Internet</strong><br />

09/18/2009<br />

Site Ownership<br />

• High number <strong>of</strong> commercial websites<br />

• Only small amount <strong>of</strong> private <strong>and</strong><br />

institutional/governmental websites<br />

Holger Siemann (holger.siemann@lvr.de)<br />

8


<strong>Misuse</strong> <strong>and</strong> <strong>Abuse</strong> <strong>of</strong> <strong>Opioid</strong> <strong>Analgesics</strong> – <strong>the</strong> <strong>Role</strong> <strong>of</strong> <strong>the</strong> <strong>Internet</strong><br />

09/18/2009<br />

Trading<br />

• Smart/Head/Herbal shops focus on herbal drugs<br />

• Online pharmacies focus on life-style drugs<br />

Holger Siemann (holger.siemann@lvr.de)<br />

9


<strong>Misuse</strong> <strong>and</strong> <strong>Abuse</strong> <strong>of</strong> <strong>Opioid</strong> <strong>Analgesics</strong> – <strong>the</strong> <strong>Role</strong> <strong>of</strong> <strong>the</strong> <strong>Internet</strong><br />

09/18/2009<br />

<strong>Role</strong> as a Trading Platform<br />

• Only a low number <strong>of</strong> opioid drug distributing<br />

websites<br />

– Interdiction <strong>of</strong> „online“ prescriptions in Germany<br />

need for valid prescription<br />

2 sites from <strong>the</strong> Ne<strong>the</strong>rl<strong>and</strong>s <strong>of</strong>fering online<br />

prescription<br />

– Need for a credit card<br />

– Delayed access<br />

– Suspicion because <strong>of</strong> high quality fake sites<br />

(credit card number phising, money transfer)<br />

Holger Siemann (holger.siemann@lvr.de)<br />

10


<strong>Misuse</strong> <strong>and</strong> <strong>Abuse</strong> <strong>of</strong> <strong>Opioid</strong> <strong>Analgesics</strong> – <strong>the</strong> <strong>Role</strong> <strong>of</strong> <strong>the</strong> <strong>Internet</strong><br />

09/18/2009<br />

<strong>Role</strong> as an Information System<br />

• Mainly a pro-drug consumption attitude<br />

– Many commercial sites<br />

– Use <strong>of</strong> tramadol as a regular analgesic<br />

drug: „if my doctor is prescribing this drug<br />

it can‘t be harmful“<br />

• Information about methods to obtain<br />

opioid analgesics<br />

Holger Siemann (holger.siemann@lvr.de)<br />

11


<strong>Misuse</strong> <strong>and</strong> <strong>Abuse</strong> <strong>of</strong> <strong>Opioid</strong> <strong>Analgesics</strong> – <strong>the</strong> <strong>Role</strong> <strong>of</strong> <strong>the</strong> <strong>Internet</strong><br />

09/18/2009<br />

Examples<br />

• Tilidine + Naloxone:<br />

– Different boiling points<br />

– Usage <strong>of</strong> toaster to separate both substances<br />

from each o<strong>the</strong>r<br />

Inhalation <strong>of</strong> Tilidine<br />

• Tramadol:<br />

– How to get your doctor to prescribe an<br />

opioid analgesic (e.g. chronic pain)<br />

– How to forge a prescription<br />

Holger Siemann (holger.siemann@lvr.de)<br />

12


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