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Technical Aspects of PPI Test<br />

Cut-off value<br />

- Defining optimal cut-off value is important in the accuracy of the test<br />

- 50 – 75% improvement of symptoms<br />

Dosage<br />

- As strong as possible to acid-secretion inhibitory effect<br />

- Two (or four) times therapeutic dosage<br />

Duration<br />

- Steady-state inhibition of acid secretion<br />

- Frequent GERD symptom : 7 days<br />

- less frequent atypical symptom : 14 days<br />

Bruley des Varannes S et al. Eur J Gastroenterol t Hepatol. 8:309-314, 314 2004<br />

<strong>UNIVERSITY</strong> <strong>OF</strong> <strong>ULSAN</strong> <strong>COLLEGE</strong> <strong>OF</strong> <strong>MEDICINE</strong>, <strong>ASAN</strong> MEDICAL CENTER

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