Molecular Programming - Luca Cardelli

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What can we do with “just” DNA? Organize ANY matter [caveats apply] Execute ANY kinetics [caveats: up to time scaling] Build Nano-Control Devices Interface to Biology H.Lodish & al. <strong>Molecular</strong> Cell Biology 4 th ed.
Organizing Any Matter Use one kind of programmable matter (e.g. DNA). To organize (almost) ANY matter through it. 6 nm grid of individually addressable DNA pixels + European Nanoelectronics Initiative Advisory Council "What we are really making are tiny DNA circuit boards that will be used to assemble other components." Greg Wallraff, IBM PWK Rothemund, Nature 440, 297 (2006)
Page 1 and 2: Molecular Programming Luca Cardelli
Page 3 and 4: The Hardware Argument Smaller and s
Page 5 and 6: Building the Smallest Things How d
Page 7 and 8: Programmed Self-Assembly Proteins D
Page 9 and 10: We can program... Computers. Comp
Page 11: We can program... Matter Complete
Page 15 and 16: Building Nano-Control Devices All
Page 17 and 18: The Biological Argument Biological
Page 19 and 20: Biological Languages Gene Networks
Page 21 and 22: Molecular Languages ... that we can
Page 23 and 24: Our Assembly Language: Chemistry A
Page 25 and 26: How do we “run” Chemistry? Che
Page 27 and 28: The role of DNA Computing Non-goal
Page 29 and 30: Short Domains t t t DNA double stra
Page 31 and 32: Strand Displacement t t x x “Toeh
Page 33 and 34: Strand Displacement t x Branch Migr
Page 35 and 36: Strand Displacement x t x Irreversi
Page 37 and 38: Bad Match t x x z y
Page 39 and 40: Bad Match t x z y Cannot proceed He
Page 41 and 42: Plasmidic Gate Technology Syntheti
Page 43 and 44: Transducer x→y t Input x t a y t
Page 45 and 46: Transducer x→y t a y t t x t a t
Page 47 and 48: Transducer x→y x t y t t x t a t
Page 49 and 50: Transducer x→y x t y t t x t a t
Page 51 and 52: Transducer x→y x t t a t x t a t
Page 53 and 54: Transducer x→y x t Output t a t y
Page 55 and 56: Transducer x→y x Output t a t y t
Page 57 and 58: Transducer x→y a x t Output y t x
Page 59 and 60: Transducer x→y
Page 61 and 62: Tools and Techniques A software pip
Page 63 and 64:
Molecular Compilation Programs “H
Page 65 and 66:
A Language for DNA Structures Desc
Page 67 and 68:
Reaction Graph and Export
Page 69 and 70:
State Space Analysis
Page 71 and 72:
Verification Quantitative theories
Page 73 and 74:
Execution A software/wetware pipeli
Page 75 and 76:
From Structures to Sequences www.nu
Page 77 and 78:
From Sequences to Molecules Copy&P
Page 79 and 80:
Add Water
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Output
Page 83 and 84:
Delivery!
Page 85 and 86:
Approximate Majority Algorithm Giv
Page 87 and 88:
DNA Implementation, at U.W. Progra
Page 89 and 90:
A Brief History of DNA Turing Machi
Page 91 and 92:
Questions?
Page 93:
©2013 Microsoft Corporation. All r
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Molecular Programming - Luca Cardelli

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