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Definition iti of Classic HIT 1.Thrombocytopenia < 100,000 – 150,000 mm 3 (may not always see very low counts) or a 50% drop in platelet count from baseline (more powerful) 2.Exclusion of other causes of thrombocytopenia 3.With or without thrombotic <strong>com</strong>plications
Therapy for HIT Interruption of the immune response (eg. discontinue heparin) Reduce thrombin generation (thrombin inhibitors) Treatment of thrombosis
Page 1: An Alternative Anticoagulant Craig
Page 4 and 5: McLean Discovered heparin to reduce
Page 6 and 7: Heparin and Protamine -- Perfect Pa
Page 8 and 9: Historical Perspective - 1960s and
Page 10 and 11: New Challenges PTCA Stents Drug Ste
Page 12 and 13: Thrombosis in HIT High risk for ven
Page 16 and 17: Ancrod Malaysain Pit Viper
Page 18 and 19: Hirudin / Lepirudin / Bivalrudin Cl
Page 20 and 21: Bivalurudin Direct Thrombin Inhibit
Page 22 and 23: Bivalirudin in CPB Off - label use
Page 24 and 25: Differences and Concerns Bolus and
Page 26 and 27: Anticoagulation ACT 2.5 X Baseline
Page 28 and 29: Circuit Non coated circuit Add A-V
Page 30 and 31: Hemoconcentration ACT bolus of 0.3m
Page 32 and 33: Cell Saver Citrate as anticoagulant
Page 34 and 35: Anticoagulation Monitoring A kaolin
Page 36 and 37: Use of Bivalirudin During CPB Cardi
Page 38 and 39: Special Considerations Cell saver u
Page 40 and 41: Once again…. This is not heparin
Page 42: One final question Does anyone reco

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