David Price - Progetto LIBRA

Thomas M, von Ziegenweidt J, Lee AJ, Price D. High-dose inhaled corticosteroids versus add-on long-acting beta -agonists in
asthma: An observational study. J Allergy Clin Immunol 2009;123:116-21
General Practice Research Database of “real‐life”
increasing ICS or adding a LABA
Inclusion criteria:
‐ Min 12 months data in both baseline and outcome periods
‐ GP diagnosis of asthma and no COPD receiving ICS
Success definition based on proxy of GINA control including SABA
and oral steroid use
Index event:
first change is +LABA or increase ICS
0
-12m +12m
Prescribed ICS
Baseline period
• confounding factor definition
Outcome period
• outcome comparison
• adjusted for baseline confounders
Dec 1990 – Jan 2004