Alternative Methods in the Safety Assessment of Fragrance Ingredients
Alternative Methods in the Safety Assessment of Fragrance Ingredients
Alternative Methods in the Safety Assessment of Fragrance Ingredients
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Sk<strong>in</strong> Absorption -<br />
Experimental Studies<br />
• Historically, RIFM has utilized <strong>in</strong> vivo methodologies<br />
to <strong>in</strong>vestigate i <strong>the</strong> percutaneous penetration <strong>of</strong><br />
fragrance materials<br />
• RIFM has fully transitioned to human <strong>in</strong> vitro studies<br />
• A grow<strong>in</strong>g g <strong>in</strong> vitro dataset (recently published) has<br />
developed for key fragrance materials that will…<br />
1. Allow for comparative analysis based on structure and<br />
vehicle <strong>of</strong> adm<strong>in</strong>istration (important for group risk<br />
assessments)<br />
2. Assist <strong>the</strong> development and ref<strong>in</strong>ement <strong>of</strong><br />
ma<strong>the</strong>matical models<br />
J Lalko - May 26 2008
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