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REVERSAL The REVERSing Atherosclerosis with Aggressive Lipid Lowering Study Nissen SE et al. JAMA 2004 291:1071-80 Nihon University School of Medicine
REVERSAL trial 1. 654 patients enrolled and 502 had evaluated by IVUS at baseline and 18mo follow up after lipid lowering therapy with Pravastatin 40mg or Atorvastatin 80mg for the patients with coronary artery disease. • Volumetric IVUS analysis was performed for plaque volume. Nissen SE et al. JAMA 2004 291:1071-80 Nihon University School of Medicine
Page 1 and 2: Role of lipid-lowering therapy Aggr
Page 3 and 4: Such lesions frequently appear as n
Page 5: Background Recent studies show that
Page 9 and 10: Background Recent studies show that
Page 11 and 12: Purpose To evaluate the combined ef
Page 13 and 14: Methods: Study Design Medication: G
Page 15 and 16: Texture Videodensitometric Analysis
Page 17 and 18: Patient Characteristics Group A Gro
Page 19 and 20: Changes in LDL-C 200 150 100 50 * *
Page 21 and 22: % change in Lumen volume *
Page 23 and 24: % changes in plaque echogenicity (%
Page 25 and 26: Changes in Plaque Area and Echogeni
Page 27 and 28: Summary 1. Increase in echogenicity

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