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Life Stages Task Force - ILSI Health and Environmental Sciences ...

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HESI<br />

<strong>ILSI</strong> <strong>Health</strong> <strong>and</strong> <strong>Environmental</strong> <strong>Sciences</strong> Institute<br />

Base set (Tier 1)<br />

Considerations of <strong>Life</strong> <strong>Stages</strong> Tiered Approach<br />

• Conduct exposure estimates (route, duration,<br />

amount)<br />

• Consider life stages to be protected<br />

• Use relevant group sizes for biological /<br />

statistical confidence in results<br />

• Include key indicators (triggers) which, if<br />

negative, give a high level of confidence of no<br />

adverse effects If positive Tier 2<br />

• Conduct risk assessment If low MOE Tier 2

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