The role of epidemiology in knowledge integration and meta

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Examples of knowledge integration at the meta-research • Associations • Predictions • Treatments level
Nutrients and cancer risk • Open a popular cookbook • Randomly check 50 ingredients • How many of those are associated with significantly increased or significantly decreased cancer risk in the scientific literature?
Page 1 and 2: The role of epidemiology in knowled
Page 3 and 4: Reprinted from Cancer Epidemiol Bio
Page 5: Reprinted from Cancer Epidemiol Bio
Page 9 and 10: Reprinted from Schoenfeld JD and Io
Page 11 and 12: Prognostic tumor markers Adapted fr
Page 13 and 14: 1 5 15 30 Effect sizes for the top-
Page 15 and 16: Field synopses Chatzinasiou F, Lill
Page 17 and 18: Replicated: only 6 of 53 landmark s
Page 19 and 20: Reproduced from Ioannidis JPA and K
Page 21 and 22: Pereira TV, Horwitz RI, and Ioannid
Page 23 and 24: Large-scale collaboration Reprinted
Page 25 and 26: Nutrient-wide association study Rep
Page 27 and 28: Improving research reporting standa
Page 29 and 30: Registration Ioannidis JPA. The Imp
Page 31 and 32: Alsheikh-Ali AA, Qureshi W, Al-Mall
Page 33 and 34: Reprinted by permission from Macmil
Page 35 and 36: From Ioannidis JPA and Khoury MJ. S

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