MODELLER - Computational Biology Service Unit (CBSU)

More documents

Recommendations

Info

• Function is the most important feature of a protein • Function is related to structure • Structure is related to sequence
Exchange of even a few residues can (and often does) change a structure and destabilizes a protein. Multiple random mutations that preserve structure are statistically unlikely. Mutations resulting in a structural change are not likely to survive since function is lost … There is a very significant evolutionary pressure for structure conservation.
Page 1: Comparative Modeling Part 1 Jarosla
Page 5 and 6: Comparative Modeling is an algorith
Page 7 and 8: 1EA5 Acetylcholinesterase Typical t
Page 9 and 10: In general model should be a little
Page 11 and 12: Modeling a putative interaction of
Page 13 and 14: MODELLER is a very popular comparat
Page 15 and 16: How does the MODELLER work? Optimiz
Page 17: Model accuracy depends on sequence
Page 21 and 22: Template selection • High sequenc
Page 23 and 24: Model evaluation. • Evaluating mo
Page 25: Problems and limitations. • Error

MODELLER - Computational Biology Service Unit (CBSU)

Create successful ePaper yourself

Delete template?

Save as template?