Intensity-Modulated Radiation Therapy (IMRT): Central Nervous ...
Intensity-Modulated Radiation Therapy (IMRT): Central Nervous ...
Intensity-Modulated Radiation Therapy (IMRT): Central Nervous ...
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Protocol<br />
<strong>Intensity</strong>-<strong>Modulated</strong> <strong>Radiation</strong> <strong>Therapy</strong> (<strong>IMRT</strong>): <strong>Central</strong> <strong>Nervous</strong><br />
System Tumors<br />
Last Review Date: 03/14<br />
The tolerance doses in the table are a compilation from the following two sources:<br />
Morgan MA (2011). <strong>Radiation</strong> Oncology. In DeVita, Lawrence and Rosenberg, Cancer (p.308). Philadelphia:<br />
Lippincott Williams and Wilkins.<br />
Kehwar TS, Sharma SC. Use of normal tissue tolerance doses into linear quadratic equation to estimate normal<br />
tissue complication probability. http://www.rooj.com/<strong>Radiation</strong>%20Tissue%20Tolerance.htm<br />
Note: This Protocol does not address radiation treatment for metastasis to the brain or spine.<br />
Services that are the subject of a clinical trial do not meet our Technology Assessment Protocol criteria and are<br />
considered investigational. For explanation of experimental and investigational, please refer to the Technology<br />
Assessment Protocol.<br />
It is expected that only appropriate and medically necessary services will be rendered. We reserve the right to<br />
conduct prepayment and postpayment reviews to assess the medical appropriateness of the above-referenced<br />
procedures. Some of this Protocol may not pertain to the patients you provide care to, as it may relate to<br />
products that are not available in your geographic area.<br />
References<br />
We are not responsible for the continuing viability of web site addresses that may be listed in any references<br />
below.<br />
1. Amelio D, Lorentini S, Schwarz M et al. <strong>Intensity</strong>-modulated radiation therapy in newly diagnosed<br />
glioblastoma: a systematic review on clinical and technical issues. Radiother Oncol 2010; 97(3):361-9.<br />
2. Gupta T, Wadasadawala T, Master Z et al. Encouraging early clinical outcomes with helical tomotherapybased<br />
image-guided intensity-modulated radiation therapy for residual, recurrent, and/or progressive<br />
benign/low-grade intracranial tumors: a comprehensive evaluation. Int J Radiat Oncol Biol Phys 2012;<br />
82(2):756-64.<br />
3. Edwards AA, Keggin E, Plowman PN. The developing role for intensity-modulated radiation therapy (<strong>IMRT</strong>) in<br />
the non-surgical treatment of brain metastases. Br J Radiol 2010; 83(986):133-6.<br />
4. Fuller CD, Choi M, Forthuber B et al. Standard fractionation intensity modulated radiation therapy (<strong>IMRT</strong>) of<br />
primary and recurrent glioblastoma multiforme. Radiat Oncol 2007; 2:26.<br />
5. MacDonald SM, Ahmad S, Kachris S et al. <strong>Intensity</strong> modulated radiation therapy versus three-dimensional<br />
conformal radiation therapy for the treatment of high grade glioma: a dosimetric comparison. J Appl Clin<br />
Med Phys 2007; 8(2):47-60.<br />
6. Narayana A, Yamada J, Berry S et al. <strong>Intensity</strong>-modulated radiotherapy in high-grade gliomas: clinical and<br />
dosimetric results. Int J <strong>Radiation</strong> Oncology Biol Phys 2006; 64(3):892-7.<br />
7. Huang E, The BS, Strother DR et al. <strong>Intensity</strong>-modulated radiation therapy for pediatric medulloblastoma:<br />
early report on the reduction of ototoxicity. Int J Radiat Oncol Biol Phys 2002; 52(3):599-605.<br />
8. Milker-Zabel S, Zabel-du BA, Huber P et al. <strong>Intensity</strong>-modulated radiotherapy for complex-shaped<br />
meningioma of the skull base: long-term experience of a single institution. Int J Radiat Oncol Biol Phys 2007;<br />
68(3):858-63.<br />
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