Role of Quantitative Clinical Pharmacology in Guiding Drug
Role of Quantitative Clinical Pharmacology in Guiding Drug
Role of Quantitative Clinical Pharmacology in Guiding Drug
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
Effect on aPTT is Concentration Dependent<br />
Concentration-aPTT relationship is similar between<br />
adults (healthy) and pediatrics (patients)<br />
200<br />
Healthy Adults<br />
Pediatric Patients<br />
Population Mean<br />
aPTT (seconds)<br />
150<br />
100<br />
50<br />
E =<br />
E<br />
0<br />
+<br />
E<br />
EC<br />
max<br />
50<br />
⋅C<br />
+ C<br />
0<br />
0.1 1 10 100 1000 10000<br />
Plasma Argatroban (ng/mL)<br />
September 24-25, 2009 OCP Ambassador Program Nit<strong>in</strong>.Mehrotra@fda.hhs.gov 20
Change language