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open wide: decoding the secrets of venom - Explore Biology

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Name __________________________________<br />

<strong>Biology</strong><br />

Dr. Fry and his colleagues report <strong>the</strong>ir study <strong>of</strong> <strong>the</strong>se toxins in<br />

<strong>the</strong> Feb. 25 issue <strong>of</strong> Biochemical and Biophysical Research<br />

Communications.<br />

They are investigating <strong>the</strong> heart-relaxing toxins for treatment <strong>of</strong><br />

congestive heart failure. By making blood vessels around <strong>the</strong><br />

heart relax, it may be possible to increase <strong>the</strong> flow <strong>of</strong> blood out<br />

<strong>of</strong> <strong>the</strong> heart.<br />

Understanding <strong>the</strong> evolution <strong>of</strong> <strong>the</strong>se <strong>venom</strong>s helps Dr. Fry<br />

and his colleagues figure out how <strong>the</strong>y work. Because <strong>the</strong>y<br />

have evolved from proteins that only act on <strong>the</strong> heart, <strong>the</strong>y<br />

probably will not pose a risk to o<strong>the</strong>r parts <strong>of</strong> <strong>the</strong> body.<br />

"If you want to use a <strong>venom</strong> for some kind <strong>of</strong> drug, you'd better<br />

look back and see where it came from," Dr. Kochva said.<br />

Dr. Fry knows that few people are as fond <strong>of</strong> deadly snakes as<br />

he is. But he hopes that <strong>the</strong>se sorts <strong>of</strong> discoveries help lead to<br />

<strong>the</strong> protection <strong>of</strong> <strong>the</strong> world's snakes.<br />

"If you kill <strong>of</strong>f <strong>the</strong> snakes, you could be killing <strong>the</strong> next wonder<br />

drug," he said.<br />

4 <strong>of</strong> 5<br />

2004-2005

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