Introduction to Statistical Thermodynamics of Soft and Biological ...
Introduction to Statistical Thermodynamics of Soft and Biological ...
Introduction to Statistical Thermodynamics of Soft and Biological ...
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Boltzmann distribution<br />
• System with many possible states (M possible states)<br />
(different conformations <strong>of</strong> protein molecule)<br />
Each state has probability<br />
Each state has energy<br />
Free energy (per one protein molecule):<br />
- normalization condition<br />
Constraint minimization<br />
• Minimize free energy with respect <strong>to</strong> :
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