2009 AnnuAl RepoRt 2009 AnnuAl RepoRt - Ciberdem
2009 AnnuAl RepoRt 2009 AnnuAl RepoRt - Ciberdem
2009 AnnuAl RepoRt 2009 AnnuAl RepoRt - Ciberdem
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Metabolomics Platform<br />
Universitat Rovira i Virgili, Institut d’Investigació Sanitària Pere Virgili, Tarragona<br />
www.metabolomicsplatform.com<br />
Principal Investigator Xavier Correig Associate researcher Jesús<br />
Brezmes, Nicolau Cañellas Research assistant Miguel Ángel<br />
Rodríguez, Maria Vinaixa PhD student Roger Mallol, Sara Samino,<br />
Julia Sigles Lab technician Antoni Beltran<br />
Keywords<br />
Lipid metabolism. Lipids, lipoproteins. Metabolomics.<br />
Bioinformatics.<br />
State of the art<br />
Metabolomics is the newest «-omics» science<br />
employed together with genomics and proteomics<br />
towards the understanding of global systems biology.<br />
It is mainly aimed at profiling all the small<br />
molecule metabolites found within body fluid,<br />
a cell, tissue, organ or organism. In diabetes<br />
and metabolic-disease research, this technique<br />
would be put to the test by its ability/capacity to<br />
assess large human populations or investigate a<br />
range of different tissues in animal studies both<br />
rapidly and cheaply, usually by high throughput<br />
screening.<br />
Main lines of research<br />
We are currently dealing with the following research<br />
areas:<br />
Lipoprotein subclass analysis and the characterization<br />
of serum samples.<br />
The identification and quantification of a wide range of<br />
metabolites in cell culture lines and different bio-fluids.<br />
The development and study of advanced statistical,<br />
chemometric, multivariate and artificial intelligence algorithms<br />
which will allow large measurement datasets<br />
to be turned into useful clinical information.<br />
The development of data mining algorithms.<br />
Areas of expertise<br />
The development of a metabolomics-based project is<br />
made up of several major operations that involve experimental<br />
design, sample handling, analytical measurements<br />
and data analysis.<br />
The platform provides expertise through all these operations<br />
which serve to enhance CIBERDEM’s research<br />
capabilities.<br />
The Metabolomics Platform facility is embedded in a<br />
strong bioinformatics environment that builds upon expertise<br />
in data management, multivariate data analysis<br />
and artificial intelligence.<br />
44 CibeRdem
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