General Principles of Pharmacology and Toxicology - Department of ...

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2 Definitions and units symbols Symbol Units Definition A mg Amount of drug in body AUC mg*hour/L Total area under the plasma drug concentration-time curve AUC 0-∞ mg*hour/L area under the plasma drug concentration-time curve from zero to infinite time AUC iv mg*hour/L area under the plasma drug concentration-time curve after an IV dose AUC oral mg*hour/L area under the plasma drug concentration-time curve after an oral dose C mg/mL Concentration of drug in plasma C 0 mg/mL Concentration of drug in plasma after a single dose extrapolated back to zero time C b mg/mL Concentration of drug in blood CL L/hour Total clearance of drug from plasma CL CR L/hour Creatinine clearance
3 Symbol Units Definition CL GF CL H L/hour L/hour Renal drug clearance by glumerular filtration Hepatic clearnce of drug from plasma CL int CL R L/hour L/hour Intrinsic clearance of drug in an organ of elimination Renal clearance of drug CL S L/hour Renal drug clearance by tubular secretion C max mg/L Maximum plasma drug concentration during a dosing interval C min mg/L Minimum plasma drug concentration during a dosing interval C ss mg/L Concentration of drug in plasma at steady state during a constant-rate intravenous infusion C uss mg/L Unbound concentration of drug in plasma at steady state during a constant-rate intravenous infusion C u mg/L Unbound drug concentration in plasma
Page 1: General Principles of Pharmacology
Page 5 and 6: 5 Symbol Units Definition F ratio B
Page 7 and 8: 7 Equations Elimination rate: CLxC
Page 9 and 10: 9 T 1/2 = 0.693/k Half-life (a reci
Page 11 and 12: 11 CL = CL R + CL H Total clearance

General Principles of Pharmacology and Toxicology - Department of ...

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