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Training Supplement - United States Special Operations Command

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Future Issues<br />

New techniques and technologies may offer great opportunities for improving combat trauma<br />

care in the future. The CoTCCC should monitor the success of all currently recommended<br />

management strategies as additional information becomes available and identify areas where<br />

modifications are needed or further research is necessary.<br />

Modified configurations of the currently used HemCon and QuikClot have recently become<br />

available (Chitoflex and the QuikClot Advanced Clotting Sponge.) In addition, a number of<br />

promising new hemostatic agents are available. The hemostatic agent options for first responders<br />

need to be reevaluated in a comparative trial using appropriate animal models.<br />

Recombinant factor VIIa has been a useful adjunct to stopping uncontrolled bleeding in animal<br />

models (Howes et al., 2007) and in medical treatment facilities (Martinowitz et al., 2004;<br />

Holcomb, 2005b). This agent may have a role in certain selected prehospital settings in military<br />

operations, especially those in areas such as Afghanistan, where evacuation times are often much<br />

longer than those in Iraq. The two most promising interventions for avoiding preventable deaths<br />

in the study by Holcomb et al. (2007a) besides proper performance of TCCC were faster<br />

CASEVAC and/or an IV hemostatic agent. The deployment strategy and the indications for the<br />

potential use of factor VIIa in the prehospital setting would both need to be carefully defined.<br />

Optimum prehospital resuscitation strategies may continue to evolve. Hemoglobin-based oxygen<br />

carrying resuscitation fluids may become available in the near term. If they are approved by the<br />

FDA, the relative merits of these agents as compared to the current Hextend resuscitation<br />

strategies should be evaluated. The aggressive administration of fresh frozen plasma in a 1:1<br />

ratio with PRBCs has been shown to decrease mortality dramatically in a hospital setting<br />

(Holcomb et al., 2007b), and this modality may have a place in selected prehospital settings.<br />

Department of Defense researchers are pursuing a comprehensive approach to fluid resuscitation<br />

that will address the multiple factors that must be considered, including preventing or reversing<br />

coagulopathies, oxygen-carrying considerations, duration of effect, and preventing<br />

iatrogenically-induced rebleeding (Holcomb et al., 2007b). The principles and technologies that<br />

ensue from these investigations will apply mostly to care in medical treatment facilities but may<br />

be useful in some prehospital settings.<br />

A common problem on the battlefield is managing severe pain in a casualty who is in shock or in<br />

danger of going into shock. Morphine and fentanyl are effective analgesics but are also<br />

cardiorespiratory depressants. Intranasal or IV ketamine or other medications that provide<br />

analgesia without depressing respiration and circulation should be evaluated for use by combat<br />

medics.<br />

28 Journal of <strong>Special</strong> <strong>Operations</strong> Medicine

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