Tst gifted 08 - Templetonfellows.org
Tst gifted 08 - Templetonfellows.org
Tst gifted 08 - Templetonfellows.org
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ANDROGEN RECEPTOR- looking for its sensitivity to androgens<br />
• Intracellular transcription factor<br />
• Gene for androgen receptor is located on chromosome X<br />
• Polymorphism in the 1st exon of AR gene – polyglutamine<br />
(CAG)n repetitive segment<br />
• Average number of repeats 21 ± 2 (normal range 9 – 37)<br />
Decreased number of CAG repeats<br />
• – higher sensitivity of AR<br />
• – higher androgenic effect<br />
ANDROGEN RECEPTOR –<br />
MEDIATOR OF TESTOSTERONE EFFECT
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