2006 Annual Report - AIME - The University of Alabama

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Spark-plug LDV, LIF, and LIL Probe for Engine Flow and Combustion Analysis would be -0.707 U jet , and the velocity value along the 2 nd and 3 rd unit vectors would be 0.5 U jet . Such an arrangement would be needed if the probe sees a velocity range of 2300 m/s. This condition is actually highly unlikely since at a measurement point the instantaneous values should not vary more than 630% of the mean value measured at that point, unless there is flow separation. A I M E 34
Multi-Functional Ionic Liquid C omp ositions For Overcoming Polymor phism And Impar ting Improved Proper ties For Active Pharmaceutical, Biological, Nutritional, And Energetic Ingredients Dr. Robin D. Rogers The subject matter disclosed herein generally relates to ionic liquids and to methods of preparing ionic liquid compositions of active pharmaceutical, biological, nutritional, and energetic ingredients. Also the subject matter disclosed generally relates to methods of using the compositions described herein to overcome polymorphism, add functionality, and improve ease of use and manufacture. The inadvertent production of an undesired polymorph (or pseudopolymorph), or the spontaneous transformation from the desired crystalline form to an undesired form, can result in crystalline forms of a drug that are less effective or even toxic. Thus, the existence and control of polymorphism and pseudopolymorphism can be the biggest challenge to obtaining a drug product of constant quality with the desired solubility and bioavailablity. The idea of multifunction IL formulations started when we were working on adding a ionic liquid sweetener to an existing ionic liquid component that had anti-bacterial properties. It soon became apparent to us that by adding specifically designed IL to ionic formulas to balance the charges we could make IL formulations with many different desirable features, such as: • • • • • • • Controlled release Controlled delivery Biological impact Taste Physical properties (stability, toxicity, melting point, etc) Melting point Methods to overcome polymorphism The ability to deliver liquid forms would have immediate acceptance in the following markets: • • • • • Drugs Pesticides Oral Care Cosmetics and Health Care Vitamins Since pharmaceuticals represent a huge market, an attractive feature to this area would be compounds whose patent life was about to expire and this could be a possible means of extending A patent life. In additional, many APIs fail due to inadequate solubility or bioavailability in addition to other I M E 35
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2006 Annual Report - AIME - The University of Alabama

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