Gulf War Illness and the Health of Gulf War Veterans Scientific ...

More documents

Recommendations

Info

1161. Ottenweller JE. Paraoxonase Activity in Gulf Era Veterans. Presentation at: Meeting of the Research Advisory Committee on Gulf War Veterans' Illnesses; June 28, 2004; East Orange, NJ. 1162. Ough EA, Lewis BJ, Andrews WS, Bennett LG, Hancock RG, Scott K. An examination of uranium levels in Canadian forces personnel who served in the Gulf War and Kosovo. Health Phys. 2002;82:527-532. 1163. Ozakinci G, Hallman WK, Kipen HM. Persistence of symptoms in veterans of the First Gulf War: 5-year follow-up. Environ Health Perspect. 2006;114:1553-1557. 1164. Page WF. Long-term health effects of exposure to sarin and other anticholinesterase chemical warfare agents. Mil Med. 2003;168:239-245. 1165. Page WF, Mahan CM, Kang HK, Bullman TA. Health effects in Army Gulf War veterans possibly exposed to chemical munitions destruction at Khamisiyah, Iraq: Part II. Morbidity associated with notification of potential exposure. Mil Med. 2005;170:945-951. 1166. Pancetti F, Olmos C, Dagnino-Subiabre A, Rozas C, Morales B. Noncholinesterase effects induced by organophosphate pesticides and their relationship to cognitive processes: implication for the action of acylpeptide hydrolase. J Toxicol Environ Health B Crit Rev. 2007;10:623-630. 1167. Paparello SF, Garst P, Bourgeois AL, Hyams KC. Diarrheal and respiratory disease aboard the hospital ship, USNS-Mercy T-AH 19, during Operation Desert Shield. Mil Med. 1993;158:392-395. 1168. Paquet F, Houpert P, Blanchardon E, et al. Accumulation and distribution of uranium in rats after chronic exposure by ingestion. Health Phys. 2006;90:139-147. 1169. Parati G, Mancia G, Di Rienzo M, Castiglioni P. Point: cardiovascular variability is/is not an index of autonomic control of circulation. J Appl Physiol. 2006;101:676-678; discussion 681-672. 1170. Parker AJ, Wessely S, Cleare AJ. The neuroendocrinology of chronic fatigue syndrome and fibromyalgia. Psychol Med. 2001;31:1331-1345. 1171. Parker KJ, Schatzberg AF, Lyons DM. Neuroendocrine aspects of hypercortisolism in major depression. Horm Behav. 2003;43:60-66. 1172. Parkhurst MA. Measuring aerosols generated inside armoured vehicles perforated by depleted uranium ammunition. Radiat Prot Dosimetry. 2003;105:167-170. 1173. Parkhurst MA, Daxon EG, Lodde GM, et al. Uranium Aerosol Doses and Risks: Summary of U.S. Assessments (Capstone Report). Richland, WA: Pacific Northwest National Laboratory; Oct, 2004. 1174. Patarca R. Cytokines and chronic fatigue syndrome. Ann N Y Acad Sci. 2001;933:185-200. 1175. Patarca-Montero R, Antoni M, Fletcher MA, Klimas NG. Cytokine and other immunologic markers in chronic fatigue syndrome and their relation to neuropsychological factors. Appl Neuropsychol. 2001;8:51-64. 1176. Patkar AA, Masand PS, Krulewicz S, et al. A randomized, controlled, trial of controlled release paroxetine in fibromyalgia. Am J Med. 2007;120:448-454. 1177. Patten SB, Beck CA, Williams JV, Barbui C, Metz LM. Major depression in multiple sclerosis: a populationbased perspective. Neurology. 2003;61:1524-1527. 1178. Pavlov VA, Ochani M, Gallowitsch-Puerta M, et al. Central muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia. Proc Natl Acad Sci U S A. 2006;103:5219-5223. 1179. Pawlikowska T, Chalder T, Hirsch SR, Wallace P, Wright DJ, Wessely SC. Population based study of fatigue and psychological distress. BMJ. 1994;308:763-766. 1180. Payne DC, Rose CE, Jr., Kerrison J, Aranas A, Duderstadt S, McNeil MM. Anthrax vaccination and risk of optic neuritis in the United States military, 1998-2003. Arch Neurol. 2006;63:871-875. 1181. Peacock MD, Morris MJ, Houghland MA, Anders GT, Blanton HM. Sleep apnea-hypopnea syndrome in a sample of veterans of the Persian Gulf War. Mil Med. 1997;162:249-251. 1182. Peakman M, Skowera A, Hotopf M. Immunological dysfunction, vaccination and Gulf War illness. Philos Trans R Soc Lond B Biol Sci. 2006;361:681-687. 1183. Pearce PC, Crofts HS, Muggleton NG, Ridout D, Scott EA. The effects of acutely administered low dose sarin on cognitive behaviour and the electroencephalogram in the common marmoset. J Psychopharmacol. 1999;13:128-135. 1184. Peckerman A, Dahl K, Chemitiganti R, LaManca JJ, Ottenweller JE, Natelson BH. Effects of posttraumatic stress disorder on cardiovascular stress responses in Gulf War veterans with fatiguing illness. Auton Neurosci. 2003;108:63-72. 1185. Peckerman A, LaManca JJ, Smith SL, et al. Cardiovascular stress responses and their relation to symptoms in Gulf War veterans with fatiguing illness. Psychosom Med. 2000;62:509-516. 1186. Peckerman A, Natelson BH, Kipen H, et al. Quantitative Sensory Testing in Gulf War Veterans with Chronic Fatigue Syndrome. Journal of Environmental Medicine. 1999;1:235-240. 1187. Peden-Adam MM, Eudaly J, Eudaly E, et al. Evaluation of immunotoxicity induced by single or concurrent exposure to N,N-diethyl-m-toluamide (DEET), pyridostigmine bromide (PYR), and JP-8 jet fuel. Toxicol Ind Health. 2001;17:192-209. 366 • Gulf War Illness and the Health of Gulf War Veterans
1188. Peden-Adams MM, Dudley AC, EuDaly JG, Allen CT, Gilkeson GS, Keil DE. Pyridostigmine bromide (PYR) alters immune function in B6C3F1 mice. Immunopharmacol Immunotoxicol. 2004;26:1-15. 1189. Peeler RN, Cluff LE, Trever RW. Hyper-immunization of man. Bull Johns Hopkins Hosp. 1958;103:183-198. 1190. Peeler RN, Kadull PJ, Cluff LE. Intensive immunization of man. Evaluation of possible adverse consequences. Ann Intern Med. 1965;63:44-57. 1191. Pellegrino MJ, Waylonis GW, Sommer A. Familial occurrence of primary fibromyalgia. Arch Phys Med Rehabil. 1989;70:61-63. 1192. Pellmar TC, Fuciarelli AF, Ejnik JW, et al. Distribution of uranium in rats implanted with depleted uranium pellets. Toxicol Sci. 1999;49:29-39. 1193. Pena-Philippides JC, Razani-Boroujerdi S, Singh SP, et al. Long- and short-term changes in the neuroimmune-endocrine parameters following inhalation exposures of F344 rats to low-dose sarin. Toxicol Sci. 2007;97:181-188. 1194. Penman AD, Tarver RS, Currier MM. No evidence of increase in birth defects and health problems among children born to Persian Gulf War Veterans in Mississippi. Mil Med. 1996;161:1-6. 1195. Perconte ST, Wilson AT, Pontius EB, Dietrick AL, Spiro KJ. Psychological and war stress symptoms among deployed and non-deployed reservists following the Persian Gulf War. Mil Med. 1993;158:516-521. 1196. Periyakaruppan A, Kumar F, Sarkar S, Sharma CS, Ramesh GT. Uranium induces oxidative stress in lung epithelial cells. Arch Toxicol. 2006. 1197. Perrin RN, Edwards J, Hartley P. An evaluation of the effectiveness of osteopathic treatment on symptoms associated with myalgic encephalomyelitis. A preliminary report. J Med Eng Technol. 1998;22:1-13. 1198. Persian Gulf Veterans Coordinating Board. A Working Plan for Research on Persian Gulf Veterans' Illnesses (First Revision). Washington, DC. Nov, 1996. 1199. Pessler F, Chen LX, Dai L, et al. A histomorphometric analysis of synovial biopsies from individuals with Gulf War Veterans' Illness and joint pain compared to normal and osteoarthritis synovium. Clin Rheumatol. 2008. 1200. Peter JB. Abnormal immune regulation in fibromyalgia. Arthritis Rheum. 1988;31:S24. 1201. Peters A, Dockery DW, Muller JE, Mittleman MA. Increased particulate air pollution and the triggering of myocardial infarction. Circulation. 2001;103:2810-2815. 1202. Petrik MS, Wong MC, Tabata RC, Garry RF, Shaw CA. Aluminum adjuvant linked to Gulf War illness induces motor neuron death in mice. Neuromolecular Med. 2007;9:83-100. 1203. Petruccelli BP, Goldenbaum M, Scott B, et al. Health effects of the 1991 Kuwait oil fires: a survey of US army troops. J Occup Environ Med. 1999;41:433-439. 1204. Petzke F, Clauw DJ. Sympathetic nervous system function in fibromyalgia. Curr Rheumatol Rep. 2000;2:116- 123. 1205. Phillips CJ. Analysis of Paraoxonase Status Among U.S. Navy Gulf War Veterans with Increased Postwar Symptoms, Psychological Morbidity, and Medical Conditions [project description]. DeployMed ResearchLink. Jul 1, 2007. Available at: http://deploymentlink.osd.mil/deploymed/projectDetail.jspprojectId=1030&region=7&researchTopic=0&ma jorDeployment=7. 1206. Phillips H. ALS risk not limited to Gulf War veterans. NewScientist.com. Apr 29, 2004. Available at: http://www.newscientist.com/article.nsid=dn4943. 1207. Pierce PF. Physical and emotional health of Gulf War veteran women. Aviat Space Environ Med. 1997;68:317-321. 1208. Pierce PF. Monitoring the health of Persian Gulf War veteran women. Federal Nursing Service Award. Mil Med. 2005;170:349-354. 1209. Pilkington A, Buchanan D, Jamal GA, et al. An epidemiological study of the relations between exposure to organophosphate pesticides and indices of chronic peripheral neuropathy and neuropsychological abnormalities in sheep farmers and dippers. Occup Environ Med. 2001;58:702-710. 1210. Pillemer SR, Bradley LA, Crofford LJ, Moldofsky H, Chrousos GP. The neuroscience and endocrinology of fibromyalgia. Arthritis Rheum. 1997;40:1928-1939. 1211. Pittman PR. Studies on the health effects of multiple vaccines: completed and ongoing. Presentation at: Meeting of the Research Advisory Committee on Gulf War Veterans' Illness; Apr 7, 2005; Washington, D.C. 1212. Pittman PR, Coonan KM, Gibbs PH, Scott HM, Cannon TL, McKee KT, Jr. Long-term health effects of repeated exposure to multiple vaccines. Vaccine. 2004;23:525-536. 1213. Pittman PR, Gibbs PH, Cannon TL, Friedlander AM. Anthrax vaccine: short-term safety experience in humans. Vaccine. 2001;20:972-978. 1214. Pittman PR, Hack D, Mangiafico J, et al. Antibody response to a delayed booster dose of anthrax vaccine and botulinum toxoid. Vaccine. 2002;20:2107-2115. References • 367
Page 1:
Gulf War Illness and the Health of
Page 4 and 5:
Research Advisory Committee on Gulf
Page 6 and 7:
Research Advisory Committee on Gulf
Page 8 and 9:
Table of Contents 2| What Caused Gu
Page 10 and 11:
Table of Contents Appendices Append
Page 12 and 13:
Gulf War illness is associated with
Page 14 and 15:
described throughout the report, sc
Page 16 and 17:
Other Health Issues Affecting Gulf
Page 18 and 19:
evidence that exposure to oil fire
Page 20 and 21:
epellants, sarin, and stress, at do
Page 22 and 23:
specialized SPECT scan analyses. In
Page 24 and 25:
amounts of PON1 differ, sometimes d
Page 26 and 27:
The Committee identified major prob
Page 28 and 29:
18 • Gulf War Illness and the Hea
Page 30 and 31:
health problems have been the subje
Page 32 and 33:
psychological stress of war to the
Page 34 and 35:
e studied as a “multisymptom illn
Page 36 and 37:
Table 1. Prevalence of Multisymptom
Page 38 and 39:
Table 2. Symptom Domains Affecting
Page 40 and 41:
likely to report a number of other
Page 42 and 43:
indicate that Gulf War illness did
Page 44 and 45:
Table 3. Effects of Confounding by
Page 46 and 47:
Gulf War Illness Prognosis and the
Page 48 and 49:
improvement on veterans’ SF36 PCS
Page 50 and 51:
was provided for Committee review i
Page 52 and 53:
Research studies have not supported
Page 54 and 55:
deployment. This excess could be of
Page 56 and 57:
have asked veterans to report if th
Page 58 and 59:
A number of theories have been put
Page 60 and 61:
children born to male Gulf War vete
Page 62 and 63:
The long-anticipated results of thi
Page 64 and 65:
affect Gulf War veterans at excess
Page 66 and 67:
Recommendations Despite the brief d
Page 68 and 69:
Operation Desert Storm: Summary of
Page 70 and 71:
The Committee used a standardized a
Page 72 and 73:
The word “stress” is used in a
Page 74 and 75:
War and the subsequent development
Page 76 and 77:
Taken together, human and animal st
Page 78 and 79:
The lack of association between com
Page 80 and 81:
Table 4. Prevalence of Post Traumat
Page 82 and 83:
Other studies have reported both hi
Page 84 and 85:
Recommendation Evidence from multip
Page 86 and 87:
winds helped to rapidly dissipate t
Page 88 and 89:
Overall, results from environmental
Page 90 and 91:
after ignition of the oil wells. Ac
Page 92 and 93:
to the risk of developing Gulf War
Page 94 and 95:
Recommendations Based on available
Page 96 and 97:
About 320 tons of DU was used durin
Page 98 and 99:
adiological and chemical effects. 1
Page 100 and 101:
Table 1. Health Effects of Depleted
Page 102 and 103:
Table 2. Brain and Behavioral Effec
Page 104 and 105:
Table 3. Genotoxic, Mutagenic, and
Page 106 and 107:
problems reported by Canadian Gulf
Page 108 and 109:
example, prolactin levels were sign
Page 110 and 111:
Recommendations Preliminary evidenc
Page 112 and 113:
Table 1. Vaccines Routinely Given t
Page 114 and 115:
shots in theater, in January and Fe
Page 116 and 117:
effects from receiving multiple vac
Page 118 and 119:
Accounting Office (GAO, now the Gov
Page 120 and 121:
Table 4. Studies Identifying Rates
Page 122 and 123:
Table 5. Studies Assessing Longer-t
Page 124 and 125:
an arthralgia-related multisymptom
Page 126 and 127:
The squalene controversy has been m
Page 128 and 129:
vaccine formulation, and concluded
Page 130 and 131:
Although squalene has been the prim
Page 132 and 133:
observation period, with improved s
Page 134 and 135:
differed from those administered pr
Page 136 and 137:
current use is the same as that of
Page 138 and 139:
Cholinergic and Related Neurotoxica
Page 140 and 141:
Pyridostigmine bromide (PB) use in
Page 142 and 143:
Table 2. Pesticides and Insect Repe
Page 144 and 145:
Although comprehensive information
Page 146 and 147:
Committee broadly reviewed informat
Page 148 and 149:
more significant symptoms and signs
Page 150 and 151:
agent as a result. But based on rou
Page 152 and 153:
Questions about Khamisiyah models a
Page 154 and 155:
Figure 2. Iraqi Chemical Weapons Fa
Page 156 and 157:
use of chemical agents during the G
Page 158 and 159:
even at higher doses. Additional ef
Page 160 and 161:
sweating. Symptoms are reported by
Page 162 and 163:
vulnerability to adverse effects of
Page 164 and 165:
Civilian use DEET formulations typi
Page 166 and 167:
disease and exposure to pesticides
Page 168 and 169:
The IOM committee also found that e
Page 170 and 171:
Table 4. Studies Evaluating Persist
Page 172 and 173:
very high, only rats with the high
Page 174 and 175:
In 1979, investigators from Harvard
Page 176 and 177:
central nervous system effects, in
Page 178 and 179:
Table 5. Effects of Combined Gulf W
Page 180 and 181:
Table 6. Animal Studies Evaluating
Page 182 and 183:
and up to 60 days in different stud
Page 184 and 185:
clinical research unit, subjects we
Page 186 and 187:
At 16 weeks, brain acetylcholine le
Page 188 and 189:
veterans with PB, pesticides, and v
Page 190 and 191:
The Committee has reviewed results
Page 192 and 193:
exposures. Although subject to conf
Page 194 and 195:
and healthcare utilization are simi
Page 196 and 197:
Recommendations During the 1990-199
Page 198 and 199:
endemic to the region and/or those
Page 200 and 201:
positive antibody titers to this vi
Page 202 and 203:
The most informative research of th
Page 204 and 205:
Table 3. Post-War Assessment of Inf
Page 206 and 207:
this activation may have resulted f
Page 208 and 209:
Anthrax causes an acute and serious
Page 210 and 211:
Recommendations Because of unanswer
Page 212 and 213:
that, during the months that oil fi
Page 214 and 215:
neurological and cardiovascular eff
Page 216 and 217:
fires and tent heaters. During the
Page 218 and 219:
control blowing sand, which may hav
Page 220 and 221:
eport indicated that of the approxi
Page 222 and 223:
Other Potential Hazards Encountered
Page 224 and 225:
Recommendations A number of exposur
Page 226 and 227:
evidence of an association was stro
Page 228 and 229:
of reasons, including the well-reco
Page 230 and 231:
findings to the Gulf War experience
Page 232 and 233:
Table 2. Gulf War Illness in Relati
Page 234 and 235:
Overview of the Evidence Linking Gu
Page 236 and 237:
War illness and low-level nerve age
Page 238 and 239:
228 • Effects of Gulf War Experie
Page 240 and 241:
Biological and Clinical Characteris
Page 242 and 243:
Brain and Central Nervous System Al
Page 244 and 245:
Table 2. Published EEG and Brain Im
Page 246 and 247:
The Committee also reviewed prelimi
Page 248 and 249:
Table 4. Neurocognitive Evaluation
Page 250 and 251:
Table 5. Neurocognitive Evaluation
Page 252 and 253:
As previously described, VA investi
Page 254 and 255:
Table 4. Published Studies of Auton
Page 256 and 257:
Many of the research limitations de
Page 258 and 259:
Table 7. Studies Assessing Sensory
Page 260 and 261:
In several recently-reported studie
Page 262 and 263:
Five of the six Gulf War projects i
Page 264 and 265:
Overall, differences between studie
Page 266 and 267:
BChE projects, was that mean BChE a
Page 268 and 269:
Table 7. Immune Evaluation of Gulf
Page 270 and 271:
specifically at T cell responses to
Page 272 and 273:
symptomatic Gulf War veterans were
Page 274 and 275:
Table 10. Clinical Findings in Symp
Page 276 and 277:
Genetic findings in symptomatic Gul
Page 278 and 279:
In attempting to understand the bio
Page 280 and 281:
Multisymptom illness associated wit
Page 282 and 283:
widespread pain, cognitive difficul
Page 284 and 285:
Gulf War Illness in Relation to Mul
Page 286 and 287:
Table 1. Prevalence of Fatigue and
Page 288 and 289:
ate of FM among family members of F
Page 290 and 291:
eported that MCS patients have sign
Page 292 and 293:
Research findings in multisymptom c
Page 294 and 295:
e common to both CFS and Gulf War i
Page 296 and 297:
Most notably, a burgeoning number o
Page 298 and 299:
Recommendations Research studies ha
Page 300 and 301:
Historical Funding and Management o
Page 302 and 303:
Since 2002, VA has sponsored a stea
Page 304 and 305:
Table 2. Examples of Psychiatric an
Page 306 and 307:
treating Gulf War illness, on long-
Page 308 and 309:
connection with the Gulf War. They
Page 310 and 311:
from the portfolio of studies ident
Page 312 and 313:
available, potentially promising tr
Page 314 and 315:
ecent data that characterize VA hea
Page 316 and 317:
The WRIISCs were established both t
Page 318 and 319:
Congressional actions have brought
Page 320 and 321:
310 • Research Priorities and Rec
Page 322 and 323:
Research to identify specific patho
Page 324 and 325:
Other Research Areas of Importance
Page 326 and 327: 316 •
Page 328 and 329: Ms. Angela Newbold, Mr. Kevin Smith
Page 330 and 331: September 19-21, 2005 (Washington,
Page 332 and 333: September 15-16, 2008 (Washington,
Page 334 and 335: 21. Abu-Qare AW, Abou-Donia MB. Det
Page 336 and 337: 73. Assefi NP, Sherman KJ, Jacobsen
Page 338 and 339: 126. Benmoyal-Segal L, Vander T, Sh
Page 340 and 341: 181. Brown VJ. Battle scars: global
Page 342 and 343: 238. Cheng Y-S. Chemical compositio
Page 344 and 345: 295. Crofford LJ, Rowbotham MC, Mea
Page 346 and 347: 349. Dockery DW, Behbehani J, Fay M
Page 348 and 349: 404. Engel CC, Hyams KC, Scott K. M
Page 350 and 351: 460. Friedman A, Kaufer D, Shemer J
Page 352 and 353: 512. Grabenstein JD. Drug interacti
Page 354 and 355: 567. Haley RW, Maddrey AM, Gershenf
Page 356 and 357: 620. Holmes DT, Tariot PN, Cox C. P
Page 358 and 359: 676. Institute of Medicine. Health
Page 360 and 361: 732. Joy RM, Walby WF, Stark LG, Al
Page 362 and 363: 786. Kellner M, Baker DG, Yehuda R.
Page 364 and 365: 836. Krengel M, Sullivan K. Neurops
Page 366 and 367: 890. Lestaevel P, Houpert P, Bussy
Page 368 and 369: 945. Mach M, Grubbs RD, Price WA, N
Page 370 and 371: 999. McDiarmid MA, Squibb K, Engelh
Page 372 and 373: 1052. Miranda ML. Spatial analysis
Page 374 and 375: 1107. Nemmar A, Hoet PH, Vanquicken
Page 378 and 379: 1215. Pittman PR, Kim-Ahn G, Pifat
Page 380 and 381: 1273. Research Working Group of Mil
Page 382 and 383: 1329. Russell IJ. Abnormal T cell s
Page 384 and 385: 1382. Seidel MF, Weinreich GF, Stra
Page 386 and 387: 1433. Smith TC, Gray GC, Weir JC, H
Page 388 and 389: 1486. Stevens D, Scott EA, Bowditch
Page 390 and 391: 1539. Tian H, Song X, Bressler J, P
Page 392 and 393: 1586. U.S. Army Environmental Hygie
Page 394 and 395: and Risk Characterization of U.S. D
Page 396 and 397: 1679. U.S. General Accounting Offic
Page 398 and 399: 1730. Vojdani A. Scientific reality
Page 400 and 401: 1786. Wijeratne C, Hickie I, Davenp
Page 403: | Appendices
Page 406 and 407: 396 • Results from Studies of Gul
Page 426 and 427:
416 • Results from Studies of Gul
Page 428 and 429:
Page 430 and 431:
Page 432 and 433:
Page 434 and 435:
Page 436 and 437:
Page 438 and 439:
Page 440 and 441:
Page 442 and 443:
Page 444 and 445:
Page 446 and 447:
Page 448 and 449:
438 • Research Advisory Committee
Page 450 and 451:
other information sources it finds
Page 452 and 453:
442 • Research Advisory Committee
Page 454 and 455:
Joel C. Graves, DMin Rev. Graves is
Page 456 and 457:
446 • Gulf War Illness and the He
Page 458 and 459:
448 • Gulf War Illness and the He
Page 460 and 461:
corr correlation CPAP Continuous Po
Page 462 and 463:
MCS MDA MDPH 2ME MEG MF59 MHPG MOD
Page 464:
Th2 TNF TSPs U.K. U.N. UNSCOM USACH
show all

Gulf War Illness and the Health of Gulf War Veterans Scientific ...

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?