Effects of N-Butanol Portion of Indigofera Pulchra - Ahmadu Bello ...

More documents

Recommendations

Info

Effects of N-Butanol Portion of Indigofera Pulchra Leaves Extract on Blood Glucose Levels of Alloxan-Induced Diabetic and Normoglycemic Wistar Rats 506 results in decreased Insulin levels and hyperglycemia leading to type 1 diabetes mellitus. However, animal models of diabetes differ significantly from each other and none can be taken, without reservation, to reproduce the essentials of human diabetes (Bell and Hyde, 1983). In the alloxan-induced diabetic groups, the effect of three doses (250mg/Kg, 500mg/Kg and 1000mg/Kg) of n-butanol portion of Indigofera pulchra, Insulin and control groups were evaluated. The dose of Insulin and the three doses of the extract did not show any significant change in the blood glucose levels when compared to untreated control after 2 and 4 hours of treatments. However, after 8 and 24 hours of treatments the dose of insulin and 250mg/Kg of the extract showed a significant (p
507 Tanko. Y, Abdelaziz. M.M, Adelaiye. A.B, Fatihu. M.Y and Musa. K.Y References [1] Abdel-Barry JA, Abdel-Hassan IA,Al-Hakiem,MHH (1997).Hypoglycemic and antihyperglycemic effects of Trigonella foenum-graecum leaf in normal and Alloxan induced diabetic rats.J Ethnopharmacol 58:149-155. [2] Abubakar M.S., Balogun E., Abdurrahman E.M., Nok A.J., Shok, M. Mohammed A. and Garba M. (2006).Ethnomedical treatment of poisonous snakebites: Plant extract neutralized Naja nigricollis venom. Pharmaceutical Biology, 44(5):343-348 [3] Abubakar, M.S., Musa, A.M.,Ahmed, A. and Husaini,I.M.(2007). The perception and practice of traditional medicine in the treatment of cancers and inflammations by the Hausa and Fulani tribes of Northern Nigeria. Journal of Ethnopharmacology, 111(3):625629. [4] Amos, A.F., McCarthy, D.J., and Zimmet, D.Z. (1997). The king global burden of diabetes and its complications part 1: diagnosis and classification of diabetes mellitus provisional report of WHO consultation. Diabet med. Vol. 15 pp. 539-553. [5] Amos, A.F., McCarthy, D.J., Zimmet, P. (1997). Diabetic Medicine 14:37-585. Ayesha, A.N., Mohammed, A.K.O. and Fraser, J.P. (2003). Type of diabetes mellitus in Africa: epidemiology and pathogenesis; Africa Health, vol. 24, No. 2, pp.13. [6] Beach, E.F., and Turner, J.J. (1958). An enzymatic method for glucose determination uptake in body fluids. Clin Chem. 4:462-468. [7] Bell,RH ,Hye,RJ (1983).Animal models of diabetes mellitus:Physiology and Pathology.J.Surg Res 35:4333-460.Burkill,H.M.(1995).The Useful Plants of West Tropical Africa .Royal botanic garden Kew, 3:361-384 [8] Brain, K. R and Turner, T. D.(1975) The Practical Evaluation of Phytopharmaceuticals, Wright Scientechnica, Bristol, pp. 57 – 58. [9] Duncan, R.C., Knapp, R.G., Miller, M.C. (1977). Test of hypothesis in population Means. In: Introductory Biostatistics for the health sciences. John Wiley and Sons Inc. NY pp.71-96. [10] Herper,F.N.(1976).The West African Herbaria of Isert and Thoning. Bentham-moxin trust in association with Carlsberg foundation, Kew, England.P 92 [11] Kamewara Rao,B.,Giri.,Kesavulu, M.M.,Apparao, CH.(1997): Herbal medicine: In the management of diabetes mellitus. Manphar Vaidhya Patrika 1(1,5)33-35. [12] Lork D 1983. A New Approach to Practical Acute Toxicity Testing Archieves of Toxicology: 275-287. [13] Mahesh, T. and Menon, P.V. (2004). Quercetin alleviates oxidative stress in streptozotocin induced diabetic rats. Phytotherapy Research, 18: 123-127. [14] Marles, J.R.and Farnsworth, N.R.1995. Antidiabetic plants and their active constituents.Phytomedicine 2 (2)123-89. [15] Pontiroli A.E., Ealdera, A., Pozza, G. (1994). Diabetes, metabolism Reveiws,vol 10,No 31. [16] Rheney, C.C., Kirk, K.K. (2000). Performance of three blood glucose meters. Ann Pharmacother. March, 34 (3) 317-21. [17] Sri Balasubashini, M., Rukkumani, R., Viswanathan, P. and Menon, P.V. (2004). Ferulic acid alleviates lipid peroxidation in diabetic rats. Phytotherapy Research, 18: 310-314. [18] Stanley,A mainzen P,Venugopal MP.(2001).Anti-oxidant action of Tinospora cordifolia root extract in alloxan diabetic rats.Phytother Res.15:213-218. [19] Sule,M.I., Pateh,U.U., Haruna,A.K., Garba,M., Ahmadu,A.A. and Adamu,A.K.(2003)Plants used in Hausa traditional medicine in Northern Nigeria.Journal of Tropical Bioscience, 3: 17-20 [20] Trease, G.E. and Evans, M.C. (1983). Textbook of Pharmacognosy, 13 th ed. Bailliere, Tindall, London, pp. 683-684. [21] WHO Expert Committee (1980). Diabetes Mellitus. Second Report, Technical Report series 64: World Health Organization Geneva. [22] World Health Organization (2006). Definition diagnoses and classification of Diabetes Mellitus and intermediate hypoglycemia Report of the WHO/IDF Consultation. Geneva, Switzerland.
Page 1 and 2: European Journal of Scientific Rese
Page 3 and 4: 503 Tanko. Y, Abdelaziz. M.M, Adela
Page 5: 505 Tanko. Y, Abdelaziz. M.M, Adela

Effects of N-Butanol Portion of Indigofera Pulchra - Ahmadu Bello ...

Create successful ePaper yourself

Delete template?

Save as template?