PPT (2 MB) - Institute for Oral Health

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Possible Mechanisms of Hyperglycemia’s Adverse Effects • Sorbitol-myoinositol osmolarity changes (via aldose reductase pathway) – AR inhibitors have not been effective in clinical trials • Oxidative-redox stress – Not effective at usual doses • Non-enzymatic glycation reactions (AGE) – AGE blocker trials stopped due to side effects • • Activation of protein kinase C (PKC) – Diacylglycerol (DAG) pathway – PKCβ iso<strong>for</strong>m inhibitor trials are in progress
HbA 1c Predicts Coronary Heart Disease in Type 2 Diabetes 25 20 15 10 5 0 CHD mortality Incidence (%) in 3.5 years Low 7.9% 25 20 15 10 5 0 All CHD events Incidence (%) in 3.5 years Low 7.9% *P
Page 1 and 2: Institute for Oral Health Conferenc
Page 3 and 4: Risk Factor Studies Changing Concep
Page 5: THE ERIE COUNTY STUDY Study Design
Page 12: Longitudinal Study of Oral Health S
Page 17 and 18: Diabetes and Periodontal Disease: L
Page 19: POPULATION 12,367 non-diabetic indi
Page 22 and 23: Obesity and Insulin Resistance: Pos
Page 24 and 25: Four Important Considerations for C
Page 26 and 27: A Diabetic Triangle I. Risk for Per
Page 28 and 29: Two Main Types of Diabetes Type 1 d
Page 30 and 31: 1990 Diabetes prevalence is increas
Page 32 and 33: Prevalence of Obesity in U.S. Adult
Page 34 and 35: Insulin Resistance: Inherited and A
Page 38 and 39: Diabetes: A Systemic Disease Leadin
Page 40 and 41: Does Periodontal Disease Affect Gly
Page 42 and 43: Can Periodontal Treatment Affect Gl
Page 45 and 46: Effect of Periodontal Disease on Mo
Page 47 and 48: • Increased Death Rate for Period
Page 49 and 50: PUBLIC HEALTH POLICY • Full RCT n
Page 51: •Thank You!

PPT (2 MB) - Institute for Oral Health

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