RSA 2011 DAILY SCHEDULE - Research Society on Alcoholism

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<strong>RSA</strong> <strong>2011</strong> <strong>DAILY</strong> <strong>SCHEDULE</strong> SUNDAY, JUNE 26 SUNDAY, JUNE 26 7:30pm - 9:30pm <strong>RSA</strong> SPONSORED POST-DOC DINNER Organized by the <strong>RSA</strong> Education Committee Chair: Sarah Pedersen If you have not already RSVPd - deadline Sunday at 12noon, if room is still available - Ticket Required. * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * MONDAY, JUNE 27 MONDAY, JUNE 27 6:30am - ......... <strong>RSA</strong> 5K FUN RUN AND WALK CENTENNIAL PARK Sign-in at 6:00am-6:25am - ask at <strong>RSA</strong> Desk for meeting place location 6:30am - 7:30am MEDITATION SESSION - led by Libby Robinson - open to all AUBURN 6:30am - 8:30am CONTINENTAL BREAKFAST - Nametag Required. CENTENNIAL FOYER 7:30am - 4:30pm <strong>RSA</strong> REGISTRATION DESK - Open CENTENNIAL FOYER 8:00am - 9:00am PLENARY SESSION II REGENCY V-VII <strong>RSA</strong> Distinguished <strong>Research</strong>er Awardees (<strong>2011</strong>) NEUROIMAGING MEETS NEUROPSYCHOLOGY: ALCOHOLIC BRAIN INJURY, NEUROADAPTATION AND RECOVERY Adolf Pfefferbaum, M.D., SRI International, Neuroscience Program, Menlo Park, CA 94025 Edith V. Sullivan, Ph.D., Department of Psychiatry and Behavioral Sciences, Stanford University, School of Medicine, Stanford, CA 94305 Adolf Pfefferbaum, M.D. is Director of the Neuroscience Program at SRI International and Professor Emeritus of Psychiatry and Behavioral Sciences at Stanford University School of Medicine. His quantitative studies using in vivo electrophysiological and neuroimaging probes of brain structure and function in chronic alcoholism have revealed brain damage with dynamic remodeling through sobriety and further insult with relapse. His NIAAA-funded neuroimaging work spans human alcoholism, its interaction with age and comorbidities, notably HIV infection, and animal models of acute and chronic alcohol exposure. Edith V. Sullivan, Ph.D. is Professor of Psychiatry and Behavioral Sciences at Stanford University School of Medicine and a neuropsychologist who has pioneered the study of the importance of alcoholic brain injury on cognitive and motor function. She is the recipient of a Senior Scientist <strong>Research</strong> and Mentorship Award and a grant for international collaborations on human alcoholism research. Both investigators are NIAAA MERIT awardees: Dr. Pfefferbaum for age-alcoholism interaction and translational studies of alcoholism, and Dr. Sullivan for functional studies of neural circuitry modification in alcoholism. Their 20-year collaboration epitomizes synergistic research and has resulted in more than 200 coauthored publications. Quantitative neuroimaging and neuropsychological studies of chronic alcoholism have revealed patterns of sparing and damage of brain structure and function. Hallmarks of alcoholism include shrinkage of brain tissue notable in frontocerebellar and limbic structures and damage to neurocircuitry that contributes to characteristic impairment in executive functions, visuospatial abilities, and gait and balance. Functional and structural imaging together with neuropsychological testing have revealed that, when able to achieve normal performance levels, alcoholics commonly recruit brain regions not invoked by healthy individuals but may do so at the price of usurping reserves needed for conducting multiple tasks simultaneously. Animal studies have complemented human investigations in elucidating the nature of alcoholism-related neuropathology, their functional ramifications, factors (age, nutrition, family history, sex, consumption patterns) contributing to heterogeneity of alcoholism’s effects, and the potential for restoration with abstinence and progression with relapse. 9:00am - 9:30am COFFEE BREAK CENTENNIAL FOYER 20
<strong>RSA</strong> <strong>2011</strong> <strong>DAILY</strong> <strong>SCHEDULE</strong> MONDAY, JUNE 27 MONDAY, JUNE 27 9:30am - 11:30am SYMPOSIUM HANOVER FG ***SYSTEMS BIOLOGY STUDIES OF ALCOHOL-INDUCED LIVER INJURY Organizers/Chairs: Q. Max Guo, Div. of Metabolism and Health Effects, NIAAA/NIH, Rockville, MD 20852 and Jan Hoek, Dept. of Pathology, Anatomy and Cell Biology, Thomas Jefferson Univ., Philadelphia, PA 19107 9:30 INTRODUCTION Marc Rigas, Office of Science Policy and Communication, NIAAA/NIH, Rockville, MD 20852 9:40 A SYSTEMS BIOLOGY PERSPECTIVE ON ETHANOL-INDUCED DEFECTS IN LIVER REPAIR AND REGENERATION Jan Hoek, Dept. of Pathology, Anatomy and Cell Biology, Thomas Jefferson Univ., Philadelphia, PA 19107 10:05 SYSTEMS BIOLOGY APPROACH TO ALCOHOL-INDUCED ENDOTOXEMIA AND ENDOTOXIN-MEDIATED INFLAMMATION AND TISSUE INJURY Ece Mutlu, Div. of Digestive Diseases and Nutrition, Rush Univ. Medical School, Chicago, IL 60612 10:30 A SYSTEMS BIOLOGY APPROACH TO THE DISCOVERY OF MECHANISMS AND BIOMARKERS OF STEATOHEPATITIS Craig McClain, Depts. of Medicine and Pharmacology & Toxicology, Univ. of Louisville, Louisville, KY 40292 10:55 GENETIC BACKGROUND-INDEPENDENT AND -DEPENDENT PATHWAYS IN ALCOHOL-INDUCED LIVER INJURY Ivan Rusyn, Dept. of Environmental Sciences and Engineering, Univ. of North Carolina, Chapel Hill, NC 27599 11:30 DISCUSSANT Q. Max Guo, Div. of Metabolism and Health Effects, NIAAA/NIH, Rockville, MD 20852 9:30am - 11:30am SYMPOSIUM REGENCY VII ALCOHOL AND THE NUTS AND BOLTS OF GENE EXPRESSION: PROMOTERS, mRNA STABILITY, MICRO RNAs AND METHYLATION Organizer/Chair: Leonardo Pignataro, Dept. of Anesthesiology, Columbia Univ., New York, NY 10032 9:30 INTRODUCTION Neil Harrison, Dept. of Anesthesiology, Columbia Univ., New York, NY 10032 9:40 ALCOHOL REGULATES GENE EXPRESSION IN NEURONS VIA ACTIVATION OF HEAT SHOCK FACTOR 1 Leonardo Pignataro, Dept. of Anesthesiology, Columbia Univ., New York, NY 10032 10:05 CIS-TRANS INTERACTIONS AND ETHANOL-MEDIATED NMDA R1 TRANSCRIPT STABILITY Meena Kumari, Dept. of Anatomy & Physiology, Kansas State Univ., Manhattan, KS 66506 10:30 POSTTRANSCRIPTIONAL REGULATION OF BK CHANNEL SPLICE VARIANT STABILITY BY miR-9 UNDERLIES NEUROADAPTATION TO ALCOHOL Steven Treistman, Dept. of Anatomy and Neurobiology, Univ. of Puerto Rico, San Juan, Puerto Rico 00901 10:55 FETAL ALCOHOL-INDUCED HYPERMETHYLATION OF PROOPIOMELANOCORTIN GENE IN THE HYPOTHALAMUS TRANSMITS THROUGH GERMLINE Dipak Sarkar, Dept. of Animal Sciences, Rutgers Univ., New Brunswick, NJ 08901 11:30 DISCUSSANT Neil Harrison, Dept. of Anesthesiology, Columbia Univ., New York, NY 10032 ***Indicates an integrative symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact. 21
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RSA 2011 DAILY SCHEDULE - Research Society on Alcoholism

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