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84 Frozen sperm may be used if the man is unable to supply fresh sperm on the day of pick-up (e.g. because he lives or has to travel abroad). The frozen sample is then thawed a few hours before insemination. However, fresh sperm is always preferred, especially when used with donated eggs, because the chances of a successful IVF outcome increase significantly. For the same reason insemination of donated eggs with sperm from the recipient woman’s partner is best done using ICSI (i.e. direct injection of one sperm into each egg). This insemination technique has a ninety percent success rate (in terms of fertilization), which is essential to have a reasonable chance of pregnancy. After all, in the case of egg donation, fewer eggs are available for each fertilization attempt. 84| ICSI. 85| Lab set up for ICSI. 86| Consent form for egg sharing. 85 86 PARTIAL DONATION A logical form of donation is partial donation (egg sharing), whereby the donor is a woman who is already having IVF treatment herself. Naturally, this applies to women who are able to produce their own fertile eggs, that will be fertilized with their partner’s sperm. One treatment, two chances Egg sharing cancels out all the objections already discussed under ‘Motivation and Risks’. The woman is already having the IVF treatment and is well aware of the potential risks and physical discomfort. The fact that she is an egg donor at the same time involves no extra burden or treatment. It is therefore standard procedure at the CRG to ask this woman, or more correctly this couple, if she or they might be willing to donate any surplus eggs. Motivation is rarely a problem because two people who use assisted fertilization techniques to achieve their dream of a child understand another couple’s problems of infertility more readily. However, it is not a foregone conclusion that every ovarian stimulation cycle will lead to the production of sufficient quantities of eggs to allow donation. Thus, while a recipient may be ready for embryo transfer, the procedure may need to be postponed if the donor has not produced sufficient eggs to allow in vitro fertilization and transfer to the other woman’s womb. DONATION Counting the eggs A certain number of eggs need to be fertilized to have a real chance of embryo development. Egg sharing donations can proceed only if ovarian stimulation has allowed the collection of at least eight ripe eggs. Half of those are reserved for the donor’s own use, the rest is donated. 102
In case of an uneven number of eggs, the extra egg goes to the donor. If ovarian stimulation only yields seven or less eggs, the egg-sharing is terminated. Surplus embryos If the in vitro fertilization produces more than the required number of embryos needed for transfer to the recipient woman’s womb, the surplus embryos are frozen and stored for transfer at a later date. Mevr. L. Van Waesberghe Laarbeeklaan 101 B-1090 Brussel Anonymous tel.: +32 2 477 88 88 fax: +32 2 477 88 89 Egg sharing donations are always anonymous, as are sperm and embryo donation. The couple who donate the eggs are not told who is to receive them, and the recipient couple are not told the identity of the donor couple. Eligible couples are those who can’t provide their own donor and thus were put on the waiting list (cfr. p. 106). NAMED DONATION VERSUS EXCHANGE DONATION Centrum Reproductieve Geneeskunde If a couple supplies its own egg donor this does not necessarily imply named donation. Exchange donation is also an option. Named donation Pressure can be considerable to opt for named donation when a couple provides its own donor. This means the couple in question will be treated exclusively with eggs collected from their donor. For the donor it can often be an ‘exclusive’ motivation to give her eggs to that specific couple. Very often, the donor is the woman’s sister or her brother’s wife. Family loyalty can also influence the recipient couple in their decisions. They have asked someone they trust to be a donor, to whom they may be related, who may even look like them and with whom they may share a common genetic history. Sometimes named donation is the only possible solution, for example when the donor the couple provide is over 35 years old, and therefore cannot be considered for inclusion in the regular donor network. Skin colour may also limit the available options. Exchange donation This donation procedure involves exchanging the donors supplied by several couples among the group. Using a well-defined, tried and tested allocation system, especially designed to exclude the possibility of a couple receiving eggs from their own donor, each 04/2007/DRUK Geachte mevrouw, U staat geregistreerd als kandidaat acceptor van eicellen en/of embryo’s in het CRG van UZ Brussel. Als u in de toekomst verder in aanmerking wil komen als acceptor, gelieve dan bij elke nieuwe menstruele cyclus waarin u een eicel of embryo zou willen ontvangen, bijgevoegd kaartje in te vullen en op te sturen. Het ingevulde kaartje moet ons in staat stellen om u op het juiste moment van uw cyclus te contacteren ingeval wij over biologisch ma- teriaal zouden beschikken. Graag terugzenden of -faxen naar: UZ Brussel CRG - Monitoring Laarbeeklaan 101 – 1090 Brussel Tel. +32 (0)2 477 66 99 – Fax +32 (0)2 477 66 49 www.brusselsivf.be Chère madame, Vous êtes sur la liste des candidates receveuses d’embryons et/ou d’ovocytes du CRG de l’UZ Brussel. Pourriez-vous remplir la fiche ci-jointe chaque fois que vous commencerez un cycle menstruel pendant lequel vous voudriez accepter un embryon ou ovocyte disponible. Veuillez bien nous envoyer cette fiche à l’adresse mentionnée ci-dessous. Cette fiche nous permettra de vous contacter au cas où nous aurions du matériel biologique disponible à un moment propice de votre cycle. ACCEPTOR RECEVEUSE Meisjesnaam / Nom de jeune fille / Dear Madam, Veuillez retourner à: Please return to: Voornaam / Prénom / UZ Brussel UZ Brussel First name k. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . CRG - Monitorage CRG - Monitoring You are enrolled on the waiting list for accepting oocytes and/or embryos of the CRG of UZ Brussel. May we kindly ask you to send to us the enclosed document – filled out – each time you start a menstrual cycle during which you are prepared to accept available oocytes and/or embryos. Please return this document to the address mentioned below. Maiden name k . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . This document will enable us to contact you in case of availabilities according to your cycle. Mevr. L. Van Waesberghe Mevr. L. Van Waesberghe Laarbeeklaan Geboortedatum 101 / Date de naissance / Laarbeeklaan 101 B-1090 Birthday Brussel k . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . B-1090 . . . . . . . . . . . Brussel . . tel.: Eerste +32 2 dag 477 van 88 88 de cyclus / Premier jour des règles tel.: / +32 2 477 88 88 fax: +32 2 477 88 89 fax: +32 2 477 88 89 First day of cycle k . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Meisjesnaam / Nom de jeune fille / Maiden name k . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Voornaam / Prénom / First name k. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Geboortedatum / Date de naissance / Birthday k . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Eerste dag van de cyclus / Premier jour des règles / First day of cycle k . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Meisjesnaam / Nom de jeune fille / Maiden name k . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Voornaam / Prénom / First name k. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Geboortedatum / Date de naissance / Birthday k . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Eerste dag van de cyclus / Premier jour des règles / First day of cycle k . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Meisjesnaam / Nom de jeune fille / Maiden name k . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Voornaam / Prénom / First name k. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Geboortedatum / Date de naissance / Birthday k . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Eerste dag van de cyclus / Premier jour des règles / First day of cycle k . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . fax +32 2 477 88 89 fax +32 2 477 88 89 fax +32 2 477 88 89 fax +32 2 477 88 89 INS-ACCEPT Meisjesnaam / Nom de jeune fille / Maiden name k . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Voornaam / Prénom / First name k. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Geboortedatum / Date de naissance / Birthday k . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Eerste dag van de cyclus / Premier jour des règles / First day of cycle k . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Meisjesnaam / Nom de jeune fille / Maiden name k . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Voornaam / Prénom / First name k. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Geboortedatum / Date de naissance / Birthday k . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Eerste dag van de cyclus / Premier jour des règles / First day of cycle k . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Meisjesnaam / Nom de jeune fille / Maiden name k . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Voornaam / Prénom / First name k. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Geboortedatum / Date de naissance / Birthday k . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Eerste dag van de cyclus / Premier jour des règles / First day of cycle k . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Meisjesnaam / Nom de jeune fille / Maiden name k . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Voornaam / Prénom / First name k. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Geboortedatum / Date de naissance / Birthday k . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Eerste dag van de cyclus / Premier jour des règles / First day of cycle k . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 87 87| The form with which a waiting list acceptor states every month that she is still a candidate for egg cell donation. fax +32 2 477 88 89 fax +32 2 477 88 89 fax +32 2 477 88 89 fax +32 2 477 88 89 The major advantage of exchange donation, medically speaking, is the two attempts with freshly donated eggs. This system gives each recipient couple two chances in each treatment cycle, thus proportionally increasing the chances of success. As mentioned above, any surplus named donation embryos can be frozen and stored for later use, but our experience of assisted fertilization shows that the chances of success are undisputedly higher using fresh donor embryos for transfer. DONATION 103
Page 1 and 2: THE MAIN POINTS All people who rely
Page 3 and 4: to allow the ‘harvesting’ of ri
Page 5 and 6: SPERM DONATION As mentioned above,
Page 7 and 8: EGG DONATION Egg donation offers th
Page 9: Finally, and strange as this may se
Page 13 and 14: contribution can have an amplified
Page 15 and 16: EMBRYO DONATION A couple’s infert

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