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Taking Control: Emerging Issues in Pain ... - Pharmacy Times

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Opioid Therapy: Exit Strategy<br />

Risks vs Benefits of Opioids<br />

• When is it appropriate to give up on opioid therapy<br />

• No conv<strong>in</strong>c<strong>in</strong>g benefit despite attempts at optimal therapy<br />

• Occurrence of comorbidity (eg, substance abuse) that<br />

substantially <strong>in</strong>creases burden or risk<br />

• Persistent adherence problems<br />

• High <strong>in</strong>dex of suspicion for diversion<br />

• Cl<strong>in</strong>ical Benefits<br />

• Demonstrated efficacy <strong>in</strong><br />

numerous randomized<br />

cl<strong>in</strong>ical trials and chronic<br />

pa<strong>in</strong> conditions<br />

• Low risk for end-organ<br />

damage<br />

• Risks<br />

• Side effects (eg,<br />

constipation, nausea,<br />

sedation)<br />

• Addiction<br />

• Abuse potential, physical<br />

dependence, tolerance<br />

Must evaluate risks vs benefits <strong>in</strong> each patient be<strong>in</strong>g<br />

considered for long-term treatment<br />

Portenoy RK. Opioid analgesics. In: Portenoy RK, Kanner RM, eds. Pa<strong>in</strong> Management: Theory and Practice.<br />

Philadelphia, PA: FA Davis Co; 1996:248-276..<br />

Long-Term Opioid Therapy:<br />

Key Po<strong>in</strong>ts<br />

Questions<br />

• Always monitor multiple outcomes:<br />

• Analgesia<br />

• Adverse effects<br />

• Activities, other functional outcomes, quality of life<br />

• Aberrant drug-related behavior<br />

• “Document for an audit”<br />

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