Taking Control: Emerging Issues in Pain ... - Pharmacy Times
Taking Control: Emerging Issues in Pain ... - Pharmacy Times
Taking Control: Emerging Issues in Pain ... - Pharmacy Times
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Opioid Therapy: Exit Strategy<br />
Risks vs Benefits of Opioids<br />
• When is it appropriate to give up on opioid therapy<br />
• No conv<strong>in</strong>c<strong>in</strong>g benefit despite attempts at optimal therapy<br />
• Occurrence of comorbidity (eg, substance abuse) that<br />
substantially <strong>in</strong>creases burden or risk<br />
• Persistent adherence problems<br />
• High <strong>in</strong>dex of suspicion for diversion<br />
• Cl<strong>in</strong>ical Benefits<br />
• Demonstrated efficacy <strong>in</strong><br />
numerous randomized<br />
cl<strong>in</strong>ical trials and chronic<br />
pa<strong>in</strong> conditions<br />
• Low risk for end-organ<br />
damage<br />
• Risks<br />
• Side effects (eg,<br />
constipation, nausea,<br />
sedation)<br />
• Addiction<br />
• Abuse potential, physical<br />
dependence, tolerance<br />
Must evaluate risks vs benefits <strong>in</strong> each patient be<strong>in</strong>g<br />
considered for long-term treatment<br />
Portenoy RK. Opioid analgesics. In: Portenoy RK, Kanner RM, eds. Pa<strong>in</strong> Management: Theory and Practice.<br />
Philadelphia, PA: FA Davis Co; 1996:248-276..<br />
Long-Term Opioid Therapy:<br />
Key Po<strong>in</strong>ts<br />
Questions<br />
• Always monitor multiple outcomes:<br />
• Analgesia<br />
• Adverse effects<br />
• Activities, other functional outcomes, quality of life<br />
• Aberrant drug-related behavior<br />
• “Document for an audit”<br />
Thank You!