Pi Mu Epsilon - Mathematical Association of America
Pi Mu Epsilon - Mathematical Association of America
Pi Mu Epsilon - Mathematical Association of America
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Thursday MAA Session #7 August 2, 2012<br />
3:20–3:35<br />
CO - Mediated Sickle Cell Polymer Melting<br />
Crystal Bennett<br />
North Carolina Agricultural & Technical State University<br />
Sickle cell anemia is a disorder caused by a mutation in DNA that replaces the nucleic acid Glutamic<br />
with Valine. This replacement causes a change in the characteristics <strong>of</strong> hemoglobin that<br />
allows the monomers, the simplest units <strong>of</strong> chemically binding molecules, to stick together. These<br />
chains <strong>of</strong> monomers, called polymers, distort the shape and properties <strong>of</strong> the red blood cell. The<br />
malformed cells do not efficiently pass through capillaries or transport oxygen to the bodys tissues.<br />
In order to make these cells more effective, the polymers must be broken apart. The process<br />
<strong>of</strong> breaking polymers apart is called melting. In the referenced study, the melting was induced<br />
by immersing the polymers in a buffer solution containing carbon monoxide. The mathematical<br />
model <strong>of</strong> this process was produced in a separate study. The purpose <strong>of</strong> this paper is to analyze<br />
and reproduce the current mathematical model using various computational and numerical tools.<br />
3:40–3:55<br />
Analysis <strong>of</strong> Spatio-Temporal Mapping<br />
Lindsay Christie<br />
Clarkson University<br />
Spatio-temporal mapping (STM) is a two-dimensional diagram which allows a user to visualize<br />
a series <strong>of</strong> movements over a spatially moving field. STM can be utilized to analyze several<br />
biological applications, including but not limited to, gastrointestinal motility. We use image decomposition<br />
<strong>of</strong> the ST maps to fully understand the frequency <strong>of</strong> the intestinal contractions that<br />
occur within Danio rerio, also known as zebrafish. In addition, we can use STMs in order to create<br />
s<strong>of</strong>tware that predicts valuable information such as the velocity and duration <strong>of</strong> each individual<br />
contraction. This can help accelerate future research pertaining to the origin <strong>of</strong> common digestive<br />
diseases and potential cures.<br />
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