GASTRIC CANCER Risk Factors And Pathology

Familial Diffuse Gastric Cancer
• Associated with germline mutations in the E-
cadherin gene
– Genetic testing in blood DNA
• Autosomal dominant: Gastric cancer develops
in 3 of every four carriers of this mutation at
young age-often multifocal
• Genetic testing and consideration of
prophylactic gastrectomy recommended
• Pathology: diagnosis of characteristic signet
ring cell carcinomas.