Antibiotic Prophylaxis for prevention of Surgical Site Infection (SSI)

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Why Ampicillin for AP 10 Advantages ¨ Cheap drug (approx US$0.50 for dose) ¨ Non-toxic, generally safe ¨ t½ = 1 hour ¨ Reasonable coverage ¨ Good tissue penetration ¨ Not otherwise used in TL5H ¨ On Kenya Essential Medicines List Concerns Possible allergic reactions – but rare Ampicillin resistance is common in clinical isolates in Kenya But ¨ Prophylaxis is to reduce inoculum rather than treat an infection Antibiotic prophylaxis for prevention of SSI
ANTIBIOTIC TREATMENT Infection with single strain of bacteria Sensitive to antibiotic ALL bacteria killed Sensitive Resistant Resistant to antibiotic No effect of treatment
Page 1 and 2: Antibiotic Prophylaxis for preventi
Page 3 and 4: SSI - how much of a problem 3 Resul
Page 5 and 6: Need for antibiotics 5 Actual need
Page 7 and 8: 7 Thika Hospital, Central Province,
Page 9: Intervention: Hospital AP Policy 9
Page 13 and 14: Results of intervention 13 Monitori
Page 15 and 16: 1. Use of antibiotics for AP in Thi
Page 17 and 18: 3. Antibiotic resistance in SSI cas
Page 19 and 20: Summary of results 19 1. Policy int
Page 21 and 22: 21 IMPROVING ANTIBIOTIC PRESCRIBI

Antibiotic Prophylaxis for prevention of Surgical Site Infection (SSI)

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