Atrial Fibrillation - The Stroke Network of Southeastern Ontario

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Comparison with Warfarin Ischemic Stroke Hemorrhagic Stroke Dabigatran Apixaban Rivaroxaban Better Same Same Better Better Better Major Bleed Same Better Same Mortality Same Better Same
What your patients need to know about novel oral anticoagulants 1. Compliance is essential. Forgetting 2 or more doses will leave them unprotected. 2. There is no antidote. If serious bleeding occurs, only supportive treatment is available at present. 3. If they are on warfarin with a well-controlled INR there is no need to switch to dabigatran. 4. They should avoid ASA and NSAIDs while on antithrombotic agents due to the increased risk of bleeding. 5. They need renal function tested annually or during acute illnesses that could impair renal function (creatinine and eGFR). 6. If not on ODB, the cost is about $100/month.
Page 1 and 2: Which Drugs to Use Dr Curry Grant S
Page 3 and 4: Objectives • Review importance of
Page 5 and 6: Importance of Atrial Fibrillation
Page 7 and 8: Assessing the Risk of Stroke CHADS2
Page 9 and 10: HAS BLED Risk Factors Risk of Bleed
Page 11 and 12: Therapies to Prevent Stroke • Ant
Page 13 and 14: Bleeding on Warfarin ICES • In pa
Page 17 and 18: Apixaban, Dabigatran and Rivaroxaba
Page 19: Clinical Trials Drug Dabigatran Api
Page 23 and 24: When should warfarin still be used
Page 25 and 26: Case Example • A 75 year-old lady
Page 27 and 28: Resources • Decision Aid by Steph
Page 29: Ischemic Stroke % /year Appendix: T

Atrial Fibrillation - The Stroke Network of Southeastern Ontario

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