is anorexia nervosa an eating disorder? - Maudsley Parents

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Brain Dopamine (DA) Optimal Response to Stimuli Schultz 1997;Horvitz 2000; Berridge 1996; Kelly 2004 • DA mediates learning and reinforcement mechanisms associated with positive rewards (food in hungry animal) • Role not selective for food but rather for signaling salience of a variety of potential rewards, or cues that predict rewards • DA encodes motivation and appropriate choices (goal directed)
Evidence for altered striatal Dopamine (DA) in AN • Reduced DA in brain (metabolite homovanillic acid (HVA) in cerebrospinal fluid) – Ill AN (Kaye 1988) – REC AN (Kaye 1999) • Altered DA gene for D2 receptor (Bergen 2005) • REC AN Increased DA D2/D3 receptor binding (Frank 2005)
Page 1 and 2: IS ANOREXIA NERVOSA AN EATING DISOR
Page 3 and 4: Mike Himes Melissa Gilmore Dina
Page 5 and 6: Anorexia Nervosa • Many women die
Page 7 and 8: Anxiety Disorders (AD) Lifetime and
Page 9 and 10: Puzzling AN Symptoms • Reduced fo
Page 11 and 12: Appetite and Weight Regulation
Page 13 and 14: % Average Body Weight and Calories/
Page 15 and 16: Systems Determining Food and Weight
Page 17 and 18: Higher Order Aspects of Feeding Rol
Page 19 and 20: Appetite Incentive Motivational Dri
Page 21 and 22: • 10% Sucrose solution • Vs wat
Page 23 and 24: Left Insula/OFC Response to Sucrose
Page 25 and 26: Insula (and connected regions) Play
Page 27 and 28: Appetite Incentive Motivational Dri
Page 29 and 30: Which Would You Rather Have But wha
Page 31: What is the balance in AN Immediate
Page 35 and 36: How to AN respond to reward fMRI -
Page 37 and 38: Left Caudate (future consequences)
Page 39 and 40: Altered Response in AN to Positive
Page 41 and 42: Altered balance in AN LIMBIC Immedi
Page 43 and 44: • Many traits are positive Vulner
Page 45 and 46: What Else T and P persists after we
Page 47 and 48: UCSD Family-Based Adolescent Progra
Page 49 and 50: Follow up on first 19 patients 14 A

is anorexia nervosa an eating disorder? - Maudsley Parents

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