Prescribing and Pharmacology of Controlled Drugs: Critical Issues ...
Prescribing and Pharmacology of Controlled Drugs: Critical Issues ...
Prescribing and Pharmacology of Controlled Drugs: Critical Issues ...
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Cognitive Impairment<br />
• “Cognitive Effects <strong>of</strong> Long-term Benzodiazepine Use:<br />
a Meta-analysis” Barker et. al. 2004 – “…all cognitive<br />
domains suggesting that long-term benzodiazepine users were<br />
significantly impaired, compared with controls, in all <strong>of</strong> the areas that<br />
were assessed.”<br />
• Cognitive Toxicity <strong>of</strong> Pharmacotherapeutic Agents Used in Social<br />
Anxiety Disorder. - Hindmarch I - Int J Clin Pract - 01-JUL-2009<br />
“Benzodiazepines caused noticeable cognitive impairment.”<br />
• “Persistence <strong>of</strong> Cognitive Effects after Withdrawal from long-term<br />
Benzodiazepine Use: a meta-analysis” Barker et. al. 2003<br />
“The findings <strong>of</strong> this study highlight the problems associated with longterm<br />
benzodiazepine therapy <strong>and</strong> suggest that previous<br />
benzodiazepine users would be likely to experience the benefit <strong>of</strong><br />
improved cognitive functioning after withdrawal. However, the<br />
reviewed data did not support full restitution <strong>of</strong> function, at least in the<br />
first 6 months following cessation <strong>and</strong> suggest that there may be some<br />
permanent deficits or deficits that take longer than 6 months to<br />
completely recover.”
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