How Mondobiotech works
How Mondobiotech works
How Mondobiotech works
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HOW�DOES<br />
<strong>Mondobiotech</strong><br />
WORK?
<strong>Mondobiotech</strong><br />
FOCUSES ON MORE THAN<br />
7000 RARE DISEASES,<br />
WHICH REPRESENT ABOUT<br />
20% OF ALL KNOWN DISEASES<br />
For�these�diseases,�<br />
there�are�only�<br />
few�drugs�available
10q Partial trisomy<br />
Achondroplasia and Swiss type agammaglobulinemia Acute monoblastic leukemia<br />
Aglossia and Situs Inversus<br />
17 Beta-hydroxysteroid dehydrogenase deficiency Achromatopsia 1<br />
Acute mountain sickness<br />
Agnosia<br />
18-Hydroxylase deficiency<br />
Achromatopsia 2<br />
Acute myeloblastic leukemia type 1<br />
Agrizoophobia<br />
18p syndrome<br />
Achromatopsia 3<br />
Acute myeloblastic leukemia type 2<br />
Agyria pachygyria polymicrogyria<br />
1p36.33 deletion<br />
Achromatopsia incomplete, x-linked<br />
Acute myeloblastic leukemia type 3<br />
Agyria-pachygyria type 1<br />
2-hydroxyethyl methacrylate sensitization<br />
Acid maltase deficiency<br />
Acute myeloblastic leukemia type 4<br />
Agyrophobia<br />
2-Hydroxyglutaricaciduria<br />
Acidemia, isovaleric<br />
Acute myeloblastic leukemia type 5<br />
Ahumada-Del Castillo syndrome<br />
2-Methylacetoacetyl CoA thiolase deficiency<br />
Acidemia, propionic<br />
Acute myeloblastic leukemia type 6<br />
Aicardi Goutieres syndrome<br />
22q11.2 deletion syndrome<br />
Acinic cell carcinoma<br />
Acute myeloblastic leukemia type 7<br />
Aicardi syndrome<br />
3 alpha methylcrotonyl-Coa carboxylase 1 deficiency Acitretine antenatal infection<br />
Acute myeloblastic leukemia with maturation Aichmophobia<br />
3 alpha methylcrotonyl-coa carboxylase 2 deficiency Ackerman syndrome<br />
Acute myeloblastic leukemia without maturation AIDS Dementia Complex<br />
3 alpha methylglutaconicaciduria, type 3<br />
Acoustic neuroma<br />
Acute myelocytic leukemia<br />
AIDS dysmorphic syndrome<br />
3-Hydroxyisobutyric aciduria<br />
Acquired agranulocytosis<br />
Acute myelogenous leukemia<br />
Ailurophobia<br />
3C syndrome<br />
Acquired amegakaryocytic thrombocytopenia<br />
Acute myeloid leukemia, adult<br />
Ainhum<br />
3M syndrome<br />
Acquired angioedema<br />
Acute myeloid leukemia, childhood<br />
Akaba Hayasaka syndrome<br />
4-Alpha-hydroxyphenylpyruvate hydroxylase deficiency Acquired hypoprothrombinemia<br />
Acute myelomonocytic leukemia<br />
Akesson syndrome<br />
4-hydroxyphenylacetic aciduria<br />
Acquired ichthyosis<br />
Acute necrotizing ulcerative gingivitis<br />
Aksu von Stockhausen syndrome<br />
46,XX Gonadal dysgenesis epibulbar dermoid<br />
Acquired prothrombin deficiency<br />
Acute non lymphoblastic leukemia (generic term) Al Awadi syndrome<br />
47 XYY syndrome<br />
Acquired pure megakaryocytic aplasia<br />
Acute posterior multifocal placoid pigment epitheliopathy Al Gazali Aziz Salem syndrome<br />
47,XXX syndrome<br />
Acral dysostosis dyserythropoiesis<br />
Acute promyelocytic leukemia<br />
Al Gazali Donnai Mueller syndrome<br />
49,XXXXX syndrome<br />
Acral lentiginous melanoma<br />
Acute respiratory distress syndrome<br />
Al Gazali Hirschsprung syndrome<br />
49,XXXXY syndrome<br />
Acro coxo mesomelic dysplasia<br />
Acute zonal occult outer retinopathy<br />
Al Gazali Khidr Prem Chandran syndrome<br />
5-alpha-Oxoprolinase deficiency<br />
Acrocallosal syndrome, Schinzel type<br />
Acyl-CoA oxidase deficiency<br />
Al Gazali Sabrinathan Nair syndrome<br />
5-Nucleotidase syndrome<br />
Acrocephalopolydactyly<br />
Adactylia unilateral dominant<br />
Alagille-Watson syndrome<br />
5q syndrome<br />
Acrocephaly pulmonary stenosis mental retardation Adams Nance syndrome<br />
Albers-Schonberg disease<br />
6 alpha mercaptopurine sensitivity<br />
Acrodermatitis<br />
Adams Oliver syndrome<br />
Albinism<br />
6-pyruvoyl-tetrahydropterin synthase deficiency Acrodermatitis enteropathica<br />
Addison's disease<br />
Albinism deafness syndrome<br />
Aagenaes syndrome<br />
Acrodysostosis<br />
Adducted thumb and clubfoot syndrome<br />
Albinism immunodeficiency<br />
Aarskog syndrome<br />
Acrodysplasia scoliosis<br />
Adducted thumb syndrome recessive form<br />
Albinism ocular late onset sensorineural deafness<br />
Aase Smith syndrome<br />
Acrofacial dysostosis ambiguous genitalia<br />
Adducted thumbs Dundar type<br />
Albinism oculocutaneous, Hermansky-Pudlak type<br />
Aase syndrome<br />
Acrofacial dysostosis atypical postaxial<br />
Adenine phosphoribosyltransferase deficiency<br />
Albinism, minimal pigment type<br />
ABCD syndrome<br />
Acrofacial dysostosis Catania form<br />
Adenoameloblastoma<br />
Albrecht Schneider Belmont syndrome<br />
Abdominal aortic aneurysm<br />
Acrofacial dysostosis Preis type<br />
Adenocarcinoid tumor<br />
Albright like syndrome<br />
Abdominal chemodectomas with cutaneous angiolipomas Acrofacial dysostosis Rodriguez type<br />
Adenocarcinoma of lung<br />
Albright's hereditary osteodystrophy<br />
Abdominal cystic lymphangioma<br />
Acrofacial dysostosis Weyers type<br />
Adenoid cystic carcinoma<br />
Alcohol antenatal infection<br />
Abdominal obesity metabolic syndrome<br />
Acrofacial dysostosis, Nager type<br />
Adenoma of the adrenal gland<br />
Aldolase A deficiency<br />
Aberrant subclavian artery<br />
Acrofacial dysostosis, Palagonia type<br />
Adenomyosis<br />
Aldred syndrome<br />
Abetalipoproteinemia<br />
Acrofrontofacionasal dysostosis syndrome<br />
Adenosarcoma of the uterus<br />
Alektorophobia<br />
Abidi X-linked mental retardation syndrome<br />
Acrokeratoelastoidosis of Costa<br />
Adenosine deaminase deficiency<br />
Aleukemic leukemia cutis<br />
Ablepharon macrostomia syndrome<br />
Adenosine monophosphate deaminase deficiency Alexander's disease<br />
Abrikosov's tumor<br />
Acromegaloid facial appearance syndrome<br />
Adenosine triphosphatase deficiency, anemia due to Alkaptonuria<br />
Abruzzo Erickson syndrome<br />
Acromegaloid hypertrichosis syndrome<br />
Adenylosuccinate lyase deficiency<br />
Allain Babin Demarquez syndrome<br />
Absence of Gluteal muscle<br />
Acromegaly<br />
Adie syndrome<br />
Allanson Pantzar McLeod syndrome<br />
Absence of septum pellucidum<br />
Acromelic frontonasal dysplasia<br />
Adiposis dolorosa<br />
Allergic angiitis<br />
Absence of Tibia<br />
Acromesomelic dysplasia<br />
Adnexal, spiradenoma/cylindroma, of a sweat gland Allergic autoimmune thyroiditis<br />
Absence of tibia with polydactyly<br />
Acromesomelic dysplasia Brahimi Bacha type Adolescent benign focal crisis<br />
Allergic bronchopulmonary aspergillosis<br />
Absent abdominal musculature with microphthalmia and joint Acromesomelic laxity dysplasia Campailla Martinelli type Adrenal adenoma, familial<br />
Allergic encephalomyelitis<br />
Absent breasts and nipples<br />
Acromesomelic dysplasia Hunter Thompson type Adrenal cancer<br />
Alliumphobia<br />
Absent corpus callosum cataract immunodeficiency Acromesomelic dysplasia, Maroteaux type<br />
Adrenal gland hyperfunction<br />
Allodoxaphobia<br />
Absent duct of Santorini<br />
Acromicric dysplasia<br />
Adrenal gland hypofunction<br />
Aloi Tomasini Isaia syndrome<br />
Absent patella<br />
Acroosteolysis dominant type<br />
Adrenal hyperplasia<br />
Alopecia anosmia deafness hypogonadism syndrome<br />
Absent T lymphocytes<br />
Acroosteolysis neurogenic<br />
Adrenal hyperplasia 2<br />
Alopecia areata<br />
Abuse dwarfism syndrome<br />
Acroosteolysis osteoporosis skull and mandible changes Adrenal hyperplasia, congenital type 3<br />
Alopecia congenita keratosis palmoplantaris<br />
Acalvaria<br />
Acropectoral syndrome<br />
Adrenal hyperplasia, congenital, due to 11-Beta-hydroxylase deficiency Alopecia contractures dwarfism mental retardation<br />
Acanthamoeba infection<br />
Acropectorenal field defect<br />
Adrenal hyperplasia, congenital, type 1<br />
Alopecia epilepsy oligophrenia syndrome of Moynahan<br />
Acanthocheilonemiasis<br />
Acropectorovertebral dysplasia<br />
Adrenal hyperplasia, congenital, type 5<br />
Alopecia hypogonadism extrapyramidal disorder<br />
Acanthoma<br />
Acrophobia<br />
Adrenal hypertension<br />
Alopecia immunodeficiency<br />
Acanthosis nigricans<br />
Acrorenal mandibular syndrome<br />
Adrenal hypoplasia congenital, X-linked<br />
Alopecia macular degeneration growth retardation<br />
Acanthosis nigricans muscle cramps acral enlargement Acrorenal syndrome recessive<br />
Adrenal incidentaloma<br />
Alopecia mental retardation hypogonadism<br />
Acarophobia<br />
Acrorenoocular syndrome<br />
Adrenal macropolyadenomatosis<br />
Alopecia mental retardation syndrome<br />
Acatalasemia<br />
Acrospiroma<br />
Adrenal medulla neoplasm<br />
Alopecia totalis<br />
Accessory deep peroneal nerve<br />
ACTH deficiency<br />
Adrenocortical carcinoma<br />
Alopecia universalis<br />
Accessory navicular bone<br />
ACTH resistance<br />
Adrenogenital syndrome<br />
Alopecia universalis onychodystrophy vitiligo<br />
Accessory pancreas<br />
Actinic cheilitis<br />
Adrenoleukodystrophy<br />
Alopecia, epilepsy, pyorrhea, mental subnormality<br />
Aceruloplasminemia<br />
Actinomycetales infection<br />
Adrenoleukodystrophy, autosomal, neonatal form Alpers disease<br />
Acetyl-coa acetyltransferase 2 deficiency<br />
Acutane embryopathy<br />
Adrenoleukodystrophy, X-linked<br />
Alpers syndrome<br />
Acetylcarnitine deficiency<br />
Acute articular rheumatism<br />
Adrenomyodystrophy<br />
Alpha 1-antitrypsin deficiency<br />
Achalasia<br />
Acute biphenotypic leukemia<br />
Adult granulosa cell tumor<br />
Alpha-2 deficient collagen disease<br />
Achalasia Addisonianism Alacrimia syndrome Acute cholinergic dysautonomia<br />
Adult low grade infiltrative supratentorial Astrocytoma Oligodendroglioma Alpha-ketoglutarate dehydrogenase deficiency<br />
Achalasia alacrimia syndrome<br />
Acute disseminated encephalomyelitis<br />
Adult onset angioedema<br />
Alpha-L-iduronidase deficiency<br />
Achalasia microcephaly<br />
Acute erythroblastic leukemia<br />
Adult onset Still's disease<br />
Alpha-mannosidosis, adult-onset form<br />
Achalasia, familial esophageal<br />
Acute erythroleukemia<br />
Adult progressive spinal muscular atrophy Aran Duchenne type Alpha-sarcoglycanopathy<br />
Achard syndrome<br />
Acute fatty liver of pregnancy<br />
Adult spinal muscular atrophy<br />
Alpha-Thalassemia<br />
Achard-Thiers syndrome<br />
Acute febrile neutrophilic dermatosis<br />
ADULT syndrome<br />
Alpha-thalassemia-abnormal morphogenesis<br />
Acheiropodia<br />
Acute hemorrhagic leukoencephalitis<br />
Advanced sleep phase syndrome<br />
Alport syndrome<br />
Achondrogenesis type 1A<br />
Acute idiopathic polyneuritis<br />
Aerophobia<br />
Alport syndrome, dominant type<br />
Achondrogenesis type 1B<br />
Acute intermittent porphyria<br />
Afibrinogenemia<br />
Alport syndrome, recessive type<br />
Achondrogenesis type 2<br />
Acute lymphoblastic leukemia congenital sporadic aniridia African trypanosomiasis<br />
Alsing syndrome<br />
Achondrogenesis, type 3<br />
Acute lymphoblastic leukemia, adult<br />
Agammaglobulinemia, non-Bruton type<br />
Alstrom syndrome<br />
Achondrogenesis, type 4<br />
Acute lymphoblastic leukemia, Childhood<br />
Aganglionosis, total intestinal<br />
Alternating hemiplegia of childhood<br />
Achondroplasia<br />
Acute megakaryoblastic leukemia<br />
Aggressive fibromatosis<br />
Aluminium lung<br />
7000<br />
Acromegaloid changes, cutis verticis gyrata and corneal leukoma<br />
Alveolar capillary dysplasia<br />
Alveolar echinococcosis<br />
Alveolar soft part sarcoma<br />
Alveolitis, extrinsic allergic<br />
Alves Castelo dos Santos syndrome<br />
Alzheimer disease type 1<br />
Alzheimer disease type 2<br />
Alzheimer disease type 4<br />
Alzheimer disease, familial<br />
Alzheimer disease, familial, type 3<br />
Alzheimer's disease without Neurofibrillary tangles<br />
Amastia<br />
Amathophobia<br />
Amaurosis congenita of Leber<br />
Amaurosis congenita of Leber, type 1<br />
Amaurosis congenita of Leber, type 2<br />
Amaurosis congenita of Leber, type 9<br />
Amaurosis fugax<br />
Amaurosis hypertrichosis<br />
Amaxophobia<br />
Ambral syndrome<br />
Ambras syndrome<br />
Ambulophobia<br />
Amebiasis<br />
Amegakaryocytic thrombocytopenia<br />
Amelia cleft lip palate hydrocephalus iris coloboma<br />
Amelia facial dysmorphism<br />
Amelogenesis imperfecta<br />
Amelogenesis Imperfecta hypomaturation type<br />
Amelogenesis imperfecta local hypoplastic form<br />
Amelogenesis imperfecta nephrocalcinosis<br />
Amelogenesis imperfecta pigmented hypomaturation type<br />
Ameloonychohypohidrotic syndrome<br />
Aminoacidopathies<br />
Aminoaciduria<br />
Aminoacylase 1 deficiency<br />
Aminopterin antenatal infection<br />
Aminopterin like syndrome without aminopterin<br />
Amniotic bands<br />
Ampola syndrome<br />
Amychophobia<br />
Amyloid angiopathy<br />
Amyloid Neuropathies<br />
Amyloid polyneuropathy, transthyretin related<br />
Amyloidosis<br />
Amyloidosis of gingiva and conjunctiva mental retardation<br />
Amyloidosis, familial visceral<br />
Amyoplasia<br />
Amyoplasia mandibulofacial dysostosis<br />
Amyotonia congenita<br />
Amyotrophic lateral sclerosis<br />
Amyotrophic lateral sclerosis type 2<br />
Amyotrophy, monomelic<br />
Anablephobia<br />
Anal Cancer<br />
Anaphylaxis<br />
Anaplastic large cell lymphoma<br />
Anaplastic small cell lymphoma<br />
Anauxetic dysplasia<br />
Ancylostoma duodenale<br />
Andersen Tawil syndrome<br />
Andersen's disease<br />
Androgen insensitivity syndrome (AIS)<br />
Androgen insensitivity syndrome, partial<br />
Androgenetic alopecia<br />
Anemia, hereditary spherocytic hemolytic<br />
Anemia, Hypoplastic, Congenital<br />
Anemia, Sideroblastic<br />
Anemia, sideroblastic spinocerebellar ataxia<br />
Anemophobia<br />
Anencephaly<br />
Anencephaly and spina bifida X linked<br />
Aneuploidy<br />
Aneurysm of sinus of Valsalva<br />
Aneurysmal bone cysts<br />
Angel shaped phalangoepiphyseal dysplasia<br />
Angelman syndrome<br />
Angiofollicular ganglionic hyperplasia<br />
Angiofollicular lymph hyperplasia<br />
Angioimmunoblastic with dysproteinemia lymphadenopathy<br />
Angiokeratoma mental retardation coarse face<br />
Angioma hereditary neurocutaneous<br />
Angiomatosis encephalotrigeminal<br />
Angiomatosis leptomeningeal capillary - venous<br />
Angiomatosis systemic cystic Seip syndrome<br />
Angiomatosis, diffuse corticomeningeal, of Divry and Van bogaert<br />
Angiomyomatous Hamartoma<br />
Angiosarcoma of the liver<br />
Angiosarcoma of the scalp<br />
Angiostrongyliasis<br />
Angiotensin renin aldosterone hypertension<br />
Anguillulosis<br />
Aniridia<br />
Aniridia absent patella<br />
Aniridia ataxia renal agenesis psychomotor retardation<br />
Aniridia cerebellar ataxia mental deficiency<br />
Aniridia mental retardation syndrome<br />
Aniridia ptosis mental retardation obesity familial<br />
Aniridia renal agenesis psychomotor retardation<br />
Aniridia type 2<br />
Aniridia, sporadic<br />
Anisakiasis<br />
Ankle defects short stature<br />
Ankyloblepharon filiforme adnatum cleft palate<br />
Ankyloblepharon filiforme imperforate anus<br />
Ankyloglossia heterochromia clasped thumbs<br />
Ankylosing spondylarthritis<br />
Ankylosis of teeth<br />
Ankylostomiasis<br />
Annular constricting bands<br />
Annular pancreas<br />
Annuloaortic ectasia<br />
Anodontia<br />
Anonychia ectrodactyly<br />
Anonychia microcephaly<br />
Anonychia onychodystrophy<br />
Anophthalmia cleft lip palate hypothalamic disorder<br />
Anophthalmia cleft palate micrognathia<br />
Anophthalmia esophageal atresia cryptorchidism<br />
Anophthalmia megalocornea cardiopathy skeletal anomalies<br />
Anophthalmia microcephaly hypogonadism<br />
Anophthalmia plus syndrome<br />
Anophthalmia short stature obesity<br />
Anophthalmia with pulmonary hypoplasia<br />
Anophthalmos with limb anomalies<br />
Anophthalmos, clinical<br />
Anorchia<br />
Anorectal atresia<br />
Anorexia nervosa<br />
Anosmia<br />
Anotia<br />
Anotia facial palsy cardiac defect<br />
Ansell Bywaters Elderking syndrome<br />
Anterior horn disease<br />
Anterior pituitary insufficiency, familial<br />
Anterior polar cataract 2<br />
Anterior spinal artery stroke<br />
Anthophobia<br />
Anthrax<br />
Anti-factor 8 autoimmunization<br />
Anti-HLA hyperimmunization<br />
Anti-plasmin deficiency, congenital<br />
Antigen-peptide-transporter 2 deficiency<br />
Antihypertensive drugs antenatal infection<br />
Antiphospholipid syndrome<br />
Antisocial personality disorder<br />
Antisynthetase syndrome<br />
Antithrombin deficiency, congenital<br />
Antley-Bixler syndrome<br />
Antlophobia<br />
Anton's syndrome<br />
Aorta-pulmonary artery fistula<br />
Aortic arch anomaly with peculiar facies and mental retardation<br />
Aortic arch interruption<br />
Aortic arches defect<br />
Aortic coarctation<br />
Aortic dissection lentiginosis<br />
Aortic supravalvular stenosis<br />
Aortic valve stenosis<br />
Aortic valves stenosis of the child<br />
Aortic window<br />
Apert like polydactyly syndrome
RARE DISEASES ≥ ORPHAN DRUG<br />
The orphan drug<br />
product is potentially<br />
useful to treat<br />
a rare disease
SOME COUNTRIES HAVE ENACTED<br />
MEASURES TO FACILITATE THE DEVELOPMENT<br />
OF THESE ORPHAN DRUGS<br />
USA<br />
Australia<br />
Japan<br />
Europe
3 1 2<br />
ALL<br />
<strong>Mondobiotech</strong><br />
PRODUCTS FULFILL<br />
THE REQUIREMENTS<br />
FOR BEING DESIGNATED<br />
AS RPHAN DRUGS
<strong>Mondobiotech</strong><br />
DOES<br />
NOT�DEVELOP<br />
NEW CHEMICAL<br />
ENTITIES<br />
( Traditional development )
Peptides<br />
<strong>Mondobiotech</strong><br />
REDIRECTS�PEPTIDES<br />
WITH PROVEN<br />
BIOLOGICAL ACTIVITY<br />
INTO RARE DISEASES<br />
rare diseases
<strong>Mondobiotech</strong><br />
PEPTIDES
PEPTIDES<br />
Peptones<br />
Peptide fragments<br />
Nonribosomal peptides<br />
Milk peptides<br />
There�are�more�than�<br />
8000�peptides�present�<br />
in�the�human�body.<br />
Ribosomal peptides
Many<br />
peptides<br />
are main<br />
constituents<br />
of human<br />
milk
PEPTIDES = SAFETY
THE Pharmacy<br />
OF <strong>Mondobiotech</strong><br />
CONSISTS OF 312<br />
PEPTIDES TO DATE
<strong>Mondobiotech</strong><br />
SEARCH�<br />
MODEL
HUNDREDS OF THOUSANDS OF SCIENTIFIC<br />
ARTICLES ARE PUBLISHED EACH YEAR
MANY ARTICLES RELATE<br />
TO RARE DISEASES OR PEPTIDES<br />
p<br />
p<br />
p<br />
p<br />
rd<br />
rd<br />
8 000 7 000<br />
p rd<br />
p<br />
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THE <strong>Mondobiotech</strong> SCIENTIFIC TEAM<br />
LINKS A PEPTIDE TO A DISEASE<br />
p<br />
Peptides +<br />
Rare Diseases<br />
Peptides<br />
Rare<br />
Diseases<br />
rd<br />
rd
<strong>Mondobiotech</strong><br />
COMMUNITY
<strong>Mondobiotech</strong><br />
Researchers<br />
THE TREATMENT<br />
OF RARE DISEASES REQUIRES A<br />
MULTI-DISCIPLINARY�<br />
APPROACH.<br />
AN OPEN, COLLABORATIVE<br />
RESEARCH COMMUNITY<br />
IS A NATURAL WAY<br />
TO INTEGRATE<br />
BIOLOGICAL AND<br />
MEDICAL NETWORKS<br />
Physicians<br />
Physicians
( iPad )<br />
OUR DEVELOPMENT<br />
MODEL IS BASED ON THE<br />
GROWTH OF THE SCIENTIFIC<br />
COMMUNITY. AN OPEN,<br />
COLLABORATIVE�<br />
RESEARCH�COMMUNITY.<br />
INFORMATION TECHNOLOGY<br />
HELPS THIS PROCESS<br />
( iPhone )<br />
( computer )
<strong>Mondobiotech</strong><br />
FREQUENTLY<br />
ORGANIZES<br />
INTERDISCIPLINARY�<br />
WORKSHOPS.<br />
THESE ARE AN INDISPENSABLE<br />
TOOL FOR DEFINING<br />
EACH PROJECT
3 1 2<br />
p<br />
Finding Therapies<br />
for Rare Diseases<br />
for�the�<br />
Patients<br />
rd
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