Physical Stability of Amorphous Formulations
Physical Stability of Amorphous Formulations
Physical Stability of Amorphous Formulations
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Heat Flow (W/g)<br />
Heat Flow (W /g)<br />
Isothermal Crystallization <strong>of</strong> Imwitor 742<br />
Imwitor 742<br />
0.4<br />
-14 o C<br />
0.3<br />
‣ A mixture <strong>of</strong> mono-/di-/triglycerides<br />
<strong>of</strong> caprylic (C8) and<br />
capric (C10) acids<br />
0.2<br />
0.1<br />
‣ Melt/Crystallize at room<br />
temperature<br />
0<br />
0 5 10 0.02 15 20 25 30<br />
Time (min)<br />
0 o C<br />
0.01<br />
0<br />
0 200 400 600 800 1000 1200 1400 1600<br />
Tim e (m in)<br />
Kawakami, Pharm Res 24, 738 (2007)
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