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The effect of exposure measurement error (aka dose uncertainties ...

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Sensitivity analysis vs. empirical<br />

correction for <strong>measurement</strong> <strong>error</strong><br />

• In the absence <strong>of</strong> validation data, the relative<br />

risk is not identifiable<br />

– Validation data: augments the usual study design<br />

with more detailed information on <strong>exposure</strong>,<br />

through an assessment via the ‘gold standard’ or<br />

an unbiased estimate <strong>of</strong> the gold standard<br />

• In the absence <strong>of</strong> validation data, sensitivity<br />

analysis can be conducted

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