Vibrio cholerae.pdf - Academic lab pages - School of Biosciences
Vibrio cholerae.pdf - Academic lab pages - School of Biosciences
Vibrio cholerae.pdf - Academic lab pages - School of Biosciences
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Cholera Toxin<br />
CT<br />
• Carried on a non-lytic bacteriophage in<br />
chromosome<br />
• 80% AA identity to ETEC heat <strong>lab</strong>ile toxin<br />
(LT)<br />
• 2 subunits<br />
• 1 x Heavy (A) = Active/toxic<br />
• 5 x Light (B) = cell binding<br />
•Export via T2SS<br />
• Binds ganglioside GM1 and is endocytosed<br />
•CTA released into cytosol - denylate<br />
cyclase AMP a uptake water<br />
secretion
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