BIOGRAPHICAL SKETCH Melinda Ryan Dwinell, Ph.D. Assistant ...

BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
Melinda Ryan Dwinell, Ph.D.
eRA COMMONS USER NAME
MRDWINELL
POSITION TITLE
Assistant Professor
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
DEGREE
(if applicable)
YEAR(s)
FIELD OF STUDY
University of Michigan, Ann Arbor, MI BS 1990 Biology/Psychology
University of Wisconsin, Madison, WI MS 1992 Veterinary Science
University of Wisconsin, Madison, WI Ph.D. 1996 Veterinary Science
Univ. of California, San Diego, CA
Postdoctoral
Fellow
1996-99 Respiratory physiology
A. Positions and Honors. List in chronological order previous positions, concluding with your
present position. List any honors. Include present membership on any Federal Government
public advisory committee.
1996-1999 Postdoctoral Trainee, University of California, San Diego
1999-2001 Project Scientist, University of California, San Diego
2001-Present Assistant Professor, Department of Physiology, Medical College of Wisconsin.
2003-2005 Member of Career Opportunities in Physiology Committee, American
Physiological Society
Honors and Awards
1993-1996 Predoctoral fellowship, National Heart Lung and Blood Institute Grant HL-07654.
1995 Veterinary Science Travel Award, University of Wisconsin-Madison
1996-1999 Postdoctoral fellowship, National Heart, Lung and Blood Institute Grant HL-
07212.
2000 Parker B. Francis Fellowship (July 1, 2000 – June 30, 2003)
2000 Frontiers in Modeling and Control of Breathing Trainee Award (Oxford
Conference, Cape Cod, MA)
B. Selected peer-reviewed publications (in chronological order). Do not include publications
submitted or in preparation. For publicly available citations, URLs or PMC submission
identification numbers may accompany the full reference. Note copies of these publications are
no longer accepted as appendix material.
1. Pizarro, J., M.M. Warner, M. Ryan, G.S. Mitchell and G.E. Bisgard. Intracarotid norepinephrine
infusions inhibit ventilation in goats. Respir. Physiol. 1992 90: 299-310.
2. Ryan, M.L., M.S. Hedrick, J. Pizarro and G.E. Bisgard. Carotid body noradrenergic sensitivity in
ventilatory acclimatization to hypoxia. Respir. Physiol. 1993 92:77-90.
3. Hedrick, M.S., M.L. Ryan, J. Pizarro and G.E. Bisgard. Modulation of respiratory rhythm by α 2 -
adrenoceptors in awake and anesthetized goats. J. Appl. Physiol. 1994 77(2):742-750.
4. Bisgard, G.E., J. Pizarro, M. Ryan and M. Hedrick. Substance P inhibits ventilation in the goat. In
"Arterial Chemoreceptors: Cell to System." R. O'Regan et al., ed. Plenum Press, New York. 1994

5. Hedrick, Michael S., Melinda L. Ryan and Gerald E. Bisgard. Modulation of Respiratory Rhythm in
the Goat by α 2 -Adrenoceptors. In: "Ventral Brainstem Mechanisms and Control of Respiration and
Blood Pressure." Ovid Trouth et al., eds. Marcel-Dekker, Inc., 1995 pp.739-754.
6. Ryan, M.L., M.S. Hedrick, J. Pizarro and G.E. Bisgard. Effects of carotid body sympathetic
denervation on ventilatory acclimatization to hypoxia in the goat. Respir. Physiol. 1995, 99:215-224.
7. Pizarro, J., M.L. Ryan, M.S. Hedrick, D.X. Xue, I.M. Keith and G.E. Bisgard. Intracarotid substance P
infusion inhibits ventilation in the goat. Respir. Physiol. 1995 101:11-21.
8. Hedrick, M.S., M.L. Ryan and G.E. Bisgard. Recurrent laryngeal nerve activation by α 2 adrenergic
agonists in goats. Respir. Physiol. 1995, 101:129-137.
9. Dwinell, Melinda R., Patrick L. Janssen, Josue Pizarro and Gerald E. Bisgard. The role of carotid
body CO 2 during ventilatory acclimatization to hypoxia in the goat. In: "Frontiers in arterial
chemoreception." P. Zapata et el., eds. Plenum Press, New York, 1996
10. Janssen, P.L., M. R. Dwinell, J. Pizarro and G.E. Bisgard. Effects of continuous intracarotid infusion
of dopamine during long-term hypoxia in awake goats. In: "Frontiers in arterial chemoreception." P.
Zapata et al., eds. Plenum Press, New York, 1996.
11. Xue, Dahai, Ingegard M. Keith, Melinda R. Dwinell and Gerald E. Bisgard. Mitochondrial division,
blood vessel dilation, and large intercellular space expansion of goat carotid body during hypoxia. In:
"Frontiers in arterial chemoreception." P. Zapata et al., eds. Plenum Press, New York, 1996.
12. Dwinell, M.R., P.L. Janssen, J. Pizarro and G.E. Bisgard. Effects of carotid body hypocapnia during
ventilatory acclimatization to hypoxia. J. Appl. Physiol. 1997 82:118-124.
13. Dwinell, M.R., P.L. Janssen and G.E. Bisgard. Lack of long term facilitation of ventilation after
exposure to hypoxia in goats. Respir. Physiol. 1997 108:1-9.
14. Janssen, P.L., K.D. O’Halloran, J. Pizarro, M.R. Dwinell and G.E. Bisgard. Carotid body
dopaminergic mechanisms are functional after acclimatization to hypoxia in goats. Respir. Physiol.
1998 111:25-32.
15. Janssen, P.L., M.R. Dwinell, J. Pizarro and G.E. Bisgard. Intracarotid dopamine infusion does not
prevent acclimatization to hypoxia. Respir. Physiol. 1998 111:33-43.
16. Hedrick, Michael S., Melinda R. Dwinell, Patrick L. Janssen, Josue Pizarro and Gerald E. Bisgard.
Differential respiratory muscle recruitment induced by clonidine in awake goats. J. Appl. Physiol.
1998, 84:1198-1207.
17. Dwinell, M.R. and F.L. Powell. Chronic hypoxia enhances the phrenic nerve response to arterial
chemoreceptor stimulation in anesthetized rats. J. Appl. Physiol. 1999, 87:817-823.
18. Dwinell, M.R., K.A. Huey and F.L. Powell. Chronic hypoxia induces changes in the central nervous
system processing of arterial chemoreceptor input. In “Oxygen sensing: molecule to man,” S. Lahiri
and N. Prabhakar, eds., Plenum Press, New York, 1999
19. Powell, F.L., Huey, K.A., and M.R. Dwinell. Central nervous system mechanisms of ventilatory
acclimatization to hypoxia. Respir. Physiol. 2000; 121(2-3):223-236.
20. Dwinell, M.R., K.A. Huey, and F.L. Powell. Chronic hypoxia induces changes in the central nervous
system processing of arterial chemoreceptor input. Adv. Exp. Med. and Bio. 475:477-484, 2000.
21. Powell, F.L., M.R. Dwinell, and E.A. Aaron. Measuring ventilatory acclimatization to hypoxia:
comparative aspects. Respir. Physiol. 2000, 122:271-284.
22. Dwinell, M.R., H. Kazemi, J.T. Lam, and F.L. Powell. Central amino acid neurotransmitters,
ventilatory output, and metabolism during acute hypoxia in anesthetized rats. Adv. Exp. Med. and
Bio. 2001, 499:291-296.
23. Olson, Jr., E.B., C.J. Bohne, M.R. Dwinell, A. Podolsky, E.H. Vidruk, D.D. Fuller, F.L. Powell, and
G.S. Mitchell. Ventilatory long term facilitation in unanesthetized rats. J. Appl. Physiol. 2001,
91:709-716.
24. Hodges MR, Forster HV, Papenek PE, Dwinell M.R., Hogan GE. Ventilatory phenotypes among four
strains of adult rats. J Appl Physiol. 2002, 93:974-83.

25. Forster HV, Dwinell MR, Hodges MR, Brozoski D, Hogan GE. Do genes on rat chromosomes 9,
13, 16, 18, and 20 contribute to regulation of breathing. Respir Physiol Neurobiol, 2003, 135:247-
261.
26. Dwinell MR, Forster HV, Petersen J, Rider A, Kunert MP, Cowley AW Jr, Jacob HJ. Genetic
determinants on rat chromosome 6 modulate variation in the hypercapnic ventilatory response using
consomic strains. J Appl Physiol, 2005, 98:1630-1638.
27. Kwitek, AE, Jacob HJ, Baker JE, Dwinell MR, Forster HV, Greene AS, Kunert MP, Lombard JH,
Mattson DL, Pritchard K, Roman RJ, Tonellato PJ, Cowely Jr. AW for PhysGen. 2006. The BN
Phenome: Detailed characterization of the cardiovascular and pulmonary systems of the
sequenced rat. Physiological Genomics, 25:303-13.
28. Kunert MP, Drenjancevic-Peric I, Dwinell MR, Lombard JH, Cowley AW Jr, Greene AS, Kwitek
AE, Jacob HJ. 2006. Consomic strategies to localize genomic regions related to vascular
reactivity in the Dahl salt-sensitive rat. Physiological Genomics, 26:218-25.
29. Davis SE, Solheid G, Castillo M, Dwinell M, Brozoski D, Forster HV. 2006. Postnatal
developmental changes in CO 2 sensitivity in rats. J Appl Physiol. 101:1097-103.
30. Mattson DL, Dwinell MR, Greene AS, Kwitek AE, Roman RJ, Cowley Jr AW, Jacob HJ. 2007.
Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats. Am J
Physiol Renal Physiol. Sep 26, 2007, Epub ahead of print.
31. Dwinell MR. 2007. Physiological genomics: from bench to bedside. Exp Physiol. 92:987.
32. Kunert MP, Dwinell MR, Drenjancevic Peric I, Lombard JH. 2008. Sex-specific differences in
chromosome-dependent regulation of vascular reactivity in female consomic rat strains from a
SSxBN cross. Am J Physiol Regul Integr Comp Physiol. 295(2):R516-27.
33. Mattson DL, Dwinell MR, Greene AS, Kwitek AE, Roman RJ, Jacob HJ, Cowley AW Jr. 2008.
Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal
disease. Am J Physiol Renal Physiol. 295(3):F837-42.
34. Dwinell MR, Worthey E, Shimoyama M, Bakir-Gungor B, DePons J, Laulederkind S, Lowry T,
Nigam R, Petri V, Smith J, Stoddard A, Twigger S, Jacob HJ. 2009. The Rat Genome Database
2009: Variation, Ontologies, and Pathways. Nucleic Acids Research. 37(Database Issue): D744-9.
C. Research Support. List selected ongoing or completed (during the last three years) research
projects (federal and non-federal support). Begin with the projects that are most relevant to the
research proposed in this application. Briefly indicate the overall goals of the projects and your
role (e.g. PI, Co-Investigator, Consultant) in the research project. Do not list award amounts or
percent effort in projects.
Ongoing support:
Title: Knock-out rats for physiologic genomics (5 U01 HL66579-08)
Principle Investigator: H.J. Jacob, Ph.D.
Agency: NIH/NHLBI
Period: 8/1/04-6/30/09
Current roles: Education Component Director, Bioinformatics Component Director, Program
Coordinator
The overall goal of this grant is to test the functionality of genes involved in mechanistic pathways
of the heart, lung, kidney, blood and vasculature by generating knockout rats.
Title: Rat Genome Database (5R01 HL64541-09)
Principle Investigator: H.J. Jacob, Ph.D.
Agency: NIH/NHLBI
Period: 9/30/99-8/31/09
Role: Co-Investigator (as of 12/1/07)

The major goals of this project are to populate the RGD with data in the following areas: ESTs,
genes, markers, primer names, genetic maps, comparative maps and supporting homology
information and UniGene Clusters.
Title: Development of bioinformatic resources to transfer biological information across species
Principle Investigator: J. Reecy, Ph.D. (Iowa State University)
Agency: USDA (subcontract through Iowa State University)
Period: 4/1/08-3/31/10
Role:
Subcontract PI
The major goals of this project are to curate rat QTLs for cardiovascular traits, develop a trait
ontology to standardize phenotype labeling for QTL across species and to develop nomenclature
for QTL in human and rat.
Completed support:
Title: Development and plasticity in respiratory control.
Principle Investigator: Melinda R. Dwinell, Ph.D.
Agency: American Lung Association
Period: 07/01/03-12/31/05
Role:
PI
The overall objective of this grant is to determine whether perinatal hyperoxia has immediate effects
on the ventilatory responses to hypoxia and hypercapnia in neonatal rats and whether these effects
have a genetic influence.