PowerPoint - Imperial College Faculty of Medicine
PowerPoint - Imperial College Faculty of Medicine
PowerPoint - Imperial College Faculty of Medicine
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Same data, different access<br />
Similar data sets can result in very different reimbursement decisions.<br />
Product<br />
(indication)<br />
Clinical data<br />
P&R outcomes<br />
Avastin<br />
(mCRC)<br />
Avastin + IFL <strong>of</strong>fers a 4.7 month<br />
median improvement in OS vs IFL<br />
+ placebo (20.3 vs 15.6 months)<br />
<br />
<br />
Not recommended by NICE or SMC<br />
Reimbursed (ASMR 2)<br />
Nexavar<br />
(RCC)<br />
Sorafenib <strong>of</strong>fers a 3 month median<br />
improvement in PFS vs placebo<br />
(24 vs 12 weeks)<br />
<br />
<br />
<br />
Not recommended by NICE or SMC<br />
Reimbursed (ASMR 2)<br />
Reimbursed with a mandatory discount (50%<br />
for first 2 cycles)<br />
Nexavar<br />
(HCC)<br />
Sorafenib <strong>of</strong>fers a 2.8 month<br />
median improvement in OS vs<br />
placebo (10.7 vs 7.9 months)<br />
<br />
<br />
<br />
Not recommended by NICE or SMC<br />
Reimbursed (ASMR 4)<br />
Reimbursed with a mandatory discount (50%<br />
for first 2 cycles)<br />
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