Z-338 - Cerep
Z-338 - Cerep
Z-338 - Cerep
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mVolts<br />
40<br />
20<br />
0<br />
a<br />
b<br />
15.258<br />
17.533<br />
19.733<br />
c<br />
40<br />
20<br />
0<br />
mVolts<br />
Z-<strong>338</strong><br />
10 µM<br />
60-min incubation<br />
rCYP2C8 (40 pmol<br />
P450/incubation)<br />
a: Z-<strong>338</strong> deisopropyl metabolite<br />
b: I.S. (ID951551)<br />
c: Z-<strong>338</strong><br />
0 5 10 15 20 25 30 35<br />
Minutes<br />
mVolts<br />
40<br />
20<br />
a<br />
13.750<br />
b<br />
c<br />
ID951551<br />
10 µM<br />
5-min incubation<br />
rCYP2C8 (40 pmol<br />
P450/incubation)<br />
0<br />
18.000<br />
0 5 10 15 20 25 30 35<br />
Minutes<br />
20.125<br />
a: ID951551 deisopropyl metabolite<br />
b: ID951551<br />
c: I.S. (Z-<strong>338</strong>)<br />
Fig. 2 HPLC Chromatograms of In Vitro Metabolism Study
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