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Postoperative implications in the geriatric patient - American ...

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Pathophysiology<br />

• The monoam<strong>in</strong>e transmitters have prom<strong>in</strong>ent<br />

neuromodulatory roles <strong>in</strong> regulat<strong>in</strong>g cognitive<br />

function, arousal, sleep, and mood, and <strong>the</strong>y are<br />

modulated by chol<strong>in</strong>ergic pathways<br />

– excess of dopam<strong>in</strong>ergic transmission has been<br />

implicated <strong>in</strong> hyperactive delirium, which can respond<br />

to antipsychotic dopam<strong>in</strong>e receptor antagonists such<br />

as haloperidol

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