Neuromuscular Junction: Development

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Remodelling of connections is activity-dependent
Activity-dependent remodelling may be based on competition for neurotrophic factors From Purves,D.(1988) Body & Brain: a trophic theory of neural connections. Harvard University Press. “When an axon of cell A is near enough to excite a cell B and repeatedly and persistently takes part in firing it, some growth process or metabolic change takes place in one or both cells such that Aʼs efficiency as one of the cells firing B is increased.” D.O.Hebb (1949) The Organization of Behaviour.
Page 1 and 2: Development of neuromuscular innerv
Page 3 and 4: The neurobiological context….
Page 5: Remodelling of connections is a fea
Page 9 and 10: Overview of motor units and their d
Page 11 and 12: Motor neurone cell bodies occupy th
Page 13 and 14: Mature NMJ’s are mononeuronally i
Page 15 and 16: Four cell types at the NMJ tSC KC N
Page 17 and 18: Neonatal muscle fibres are polyneur
Page 19 and 20: Summary of key stages in the develo
Page 21 and 22: Quantal Content (variance method) a
Page 24 and 25: The neural tube contains gradients
Page 26 and 27: Selective outgrowth of axons…
Page 28 and 29: http://www.bio.miami.edu/ktosney/
Page 30 and 31: Growth cones are semi-autonomous Re
Page 32 and 33: In immature spinal cord in vivo, ne
Page 34 and 35: Topographic projections are determi
Page 36 and 37: Myogenesis Myoblasts Myotubes Muscl
Page 39 and 40: Two types of synapse formation: FaS
Page 41 and 42: ACh Receptor maturation…
Page 43 and 44: Agrin clusters ACh receptors via Mu
Page 45 and 46: Neonate: AChR - γ Adult AChR - ε
Page 47 and 48: AChR-ε knockout mice continue to m
Page 49 and 50: Natural Motor Neurone Death…
Page 51 and 52: Target size regulates the number of
Page 53 and 54: Muscle paralysis inhibits embryonic
Page 55 and 56: Natural Synapse Elimination…
Page 57:
Physiological methods of measuring
Page 61 and 62:
Time lapse imaging of synapse elimi
Page 63 and 64:
Loss of motor neurones? Or eliminat
Page 65 and 66:
Motor unit size decreases postnatal
Page 67 and 68:
Neurones retract some of their syna
Page 69 and 70:
Neuronal/synaptic competition: “T
Page 71 and 72:
The rate of synapse elimination is
Page 73 and 74:
Transgenic expression of a growth f
Page 75 and 76:
We can determine motor unit size in
Page 77 and 78:
Motor unit sizes 2 days after parti
Page 79:
Motor units may compete in a “dom
Page 82 and 83:
Impaired NMJ form and function in n
Page 84 and 85:
Myelin formation…
Page 86 and 87:
Myelin forms from compacted Schwann
Page 88 and 89:
Regeneration…
Page 90 and 91:
MPN LPN SN 4DL
Page 92 and 93:
Axonal sprouting is preceded by Sch
Page 94 and 95:
Polyneuronal innervation (π) in re
Page 96 and 97:
…but some polyinnervation persist
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Neuromuscular Junction: Development

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